【Molecular Wt.】--

【Description】α-fetoprotein (AFP) is expressed in fetal liver at varying levels throughout development and is present only in trace amounts in normal adult tissues. AFP can be detected at abnormally high concentrations in hepatocellular carcinomas as well as in the plasma and ascitic fluid of adults with hepatoma. High AFP concentrations have been correlated with tumor cell growth, indicating that AFP can serve as a tumor marker. AFP binds copper, nickel and fatty acids, and in some cases may bind serum albumin or estrogen. It has been demonstrated that the AFP promoter is a target for NF-1 (nuclear factor-1), HNF-1 (hepatocyte nuclear factor-1) and C/EBP transcription factors. While HNF-1 binding to the AFP promoter results in AFP expression, NF-1 binding results in a decrease in AFP promoter activity.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;ICC;IHC;FC

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】Recombinant protein.

【Positive control】MCF-7, PC-12 cell lysate, human liver tissue lysate, HepG2, Hela, human liver cancer tissue, human breast cancer tissue, mouse liver tissue, 293T.

【Conjugate】Non-conjugated

【Alternative names】Afp antibody
AFPD antibody
Alpha fetoglobulin antibody
Alpha fetoprotein antibody
Alpha fetoprotein precursor antibody
Alpha-1-fetoprotein antibody
Alpha-fetoglobulin antibody
Alpha-fetoprotein antibody
alpha-fetoprotein, Hereditary persistence of, included antibody
FETA antibody
FETA_HUMAN antibody
Hereditary persistence of alpha fetoprotein antibody
HPAFP antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Secreted.

【Background References】

【DatasheetURL】http://www.huabio.com/upload/R1601-1.pdf

【Uniprot ID】P02771(Human) P02772(Mouse) P02773(Rat)

【Raised in】Rabbit

【Clone No.】