\n 产品货号\xa0:\xa0\xa0jlcR18546产品货号\xa0:\xa0\xa0jlcR18546产品货号\xa0:\xa0\xa0jlcR18546产品产品产品产品产品产品货货货货货货号号号号号号\xa0\xa0:::::\xa0\xa0\xa0\xa0jlcR18546jlcR18546jlcR18546
英文名称:\xa0\xa0macro H2A.1英文名称:\xa0\xa0macro H2A.1英文名称:\xa0\xa0macro H2A.1英文名称英文名称英文名称英文名称英文名称英文名称 :::::\xa0\xa0\xa0\xa0macro H2A.1macro H2A.1macro H2A.1macro H2A.1
中文名称:\xa0异型组蛋白H2A.1抗体中文名称:\xa0异型组蛋白H2A.1抗体中文名称:\xa0异型组蛋白H2A.1抗体中文名称中文名称中文名称中文名称中文名称中文名称 :::::\xa0异型组蛋白H2A.1抗体\xa0异型组蛋白H2A.1抗体\xa0异型组蛋白H2A.1抗体\xa0异型组蛋白H2A.1抗体\xa0异型组蛋白H2A.1抗体异型组蛋白H2A.1抗体异型组蛋白异型组蛋白H2A.1抗体抗体
别 \xa0\xa0\xa0名:\xa0\xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0别 \xa0\xa0\xa0名:\xa0\xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0别 \xa0\xa0\xa0名:\xa0\xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0别 \xa0\xa0\xa0名别 \xa0\xa0\xa0名别 \xa0\xa0\xa0名别 \xa0\xa0\xa0名别别 \xa0\xa0\xa0名名 :::::\xa0\xa0\xa0\xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0Core histone macro h2a.1; Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2afy; H2AY_HUMAN; Histone H2A.Y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU MB 50.205; Medulloblastoma antigen MU-MB-50.205; mH2a; mH2A1. \xa0
研究领域:\xa0\xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0研究领域:\xa0\xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0研究领域:\xa0\xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0研究领域研究领域研究领域研究领域研究领域研究领域 :::::\xa0\xa0\xa0\xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0细胞生物 \xa0转录调节因子 \xa0表观遗传学 \xa0细胞生物细胞生物 \xa0转录调节因子转录调节因子 \xa0表观遗传学表观遗传学 \xa0
抗体来源:\xa0\xa0Rabbit抗体来源:\xa0\xa0Rabbit抗体来源:\xa0\xa0Rabbit抗体来源抗体来源抗体来源抗体来源抗体来源抗体来源 :::::\xa0\xa0\xa0\xa0RabbitRabbitRabbitRabbit
克隆类型:\xa0\xa0Polyclonal克隆类型:\xa0\xa0Polyclonal克隆类型:\xa0\xa0Polyclonal克隆类型克隆类型克隆类型克隆类型克隆类型克隆类型 :::::\xa0\xa0\xa0\xa0PolyclonalPolyclonalPolyclonalPolyclonal
交叉反应:\xa0\xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, 交叉反应:\xa0\xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, 交叉反应:\xa0\xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, 交叉反应交叉反应交叉反应交叉反应交叉反应交叉反应 :::::\xa0\xa0\xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, \xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, \xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, \xa0Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig,
产品应用:\xa0\xa0WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.产品应用:\xa0\xa0WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.产品应用:\xa0\xa0WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.产品应用产品应用产品应用产品应用产品应用产品应用 :::::\xa0\xa0\xa0\xa0WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） （石蜡切片需做抗原修复）
not yet tested in other applications.not yet tested in other applications.not yet tested in other applications.not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.optimal dilutions/concentrations should be determined by the end user.optimal dilutions/concentrations should be determined by the end user.optimal dilutions/concentrations should be determined by the end user.
分子量:\xa0\xa039kDa分子量:\xa0\xa039kDa分子量:\xa0\xa039kDa分子量分子量分子量分子量分分 子子 量量 :::::\xa0\xa0\xa0\xa039kDa39kDa39kDa39kDa
细胞定位:\xa0\xa0细胞核细胞定位:\xa0\xa0细胞核细胞定位:\xa0\xa0细胞核细胞定位细胞定位细胞定位细胞定位细胞定位细胞定位 :::::\xa0\xa0\xa0\xa0细胞核细胞核细胞核细胞核细胞核
性 \xa0\xa0\xa0状:\xa0\xa0Lyophilized or Liquid性 \xa0\xa0\xa0状:\xa0\xa0Lyophilized or Liquid性 \xa0\xa0\xa0状:\xa0\xa0Lyophilized or Liquid性 \xa0\xa0\xa0状性 \xa0\xa0\xa0状性 \xa0\xa0\xa0状性 \xa0\xa0\xa0状性性 \xa0\xa0\xa0状状 :::::\xa0\xa0\xa0\xa0Lyophilized or LiquidLyophilized or LiquidLyophilized or LiquidLyophilized or Liquid
浓 \xa0\xa0\xa0度:\xa0\xa01mg/ml浓 \xa0\xa0\xa0度:\xa0\xa01mg/ml浓 \xa0\xa0\xa0度:\xa0\xa01mg/ml浓 \xa0\xa0\xa0度浓 \xa0\xa0\xa0度浓 \xa0\xa0\xa0度浓 \xa0\xa0\xa0度浓浓 \xa0\xa0\xa0度度 :::::\xa0\xa0\xa0\xa01mg/ml1mg/ml1mg/ml1mg/ml
免疫原:\xa0\xa0KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 免疫原:\xa0\xa0KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 免疫原:\xa0\xa0KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 免疫原免疫原免疫原免疫原免免 疫疫 原原 :::::\xa0\xa0\xa0\xa0KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372 KLH conjugated synthetic peptide derived from human macro H2A.1:1-100/372
亚 \xa0\xa0\xa0型:\xa0\xa0IgG亚 \xa0\xa0\xa0型:\xa0\xa0IgG亚 \xa0\xa0\xa0型:\xa0\xa0IgG亚 \xa0\xa0\xa0型亚 \xa0\xa0\xa0型亚 \xa0\xa0\xa0型亚 \xa0\xa0\xa0型亚亚 \xa0\xa0\xa0型型 :::::\xa0\xa0\xa0\xa0IgGIgGIgGIgG
纯化方法:\xa0\xa0affinity purified by Protein A纯化方法:\xa0\xa0affinity purified by Protein A纯化方法:\xa0\xa0affinity purified by Protein A纯化方法纯化方法纯化方法纯化方法纯化方法纯化方法 :::::\xa0\xa0\xa0\xa0affinity purified by Protein Aaffinity purified by Protein Aaffinity purified by Protein Aaffinity purified by Protein A
储存液:\xa0\xa00.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.储存液:\xa0\xa00.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.储存液:\xa0\xa00.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.储存液储存液储存液储存液储储 存存 液液 :::::\xa0\xa0\xa0\xa00.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:\xa0\xa0Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.保存条件:\xa0\xa0Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.保存条件:\xa0\xa0Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.保存条件保存条件保存条件保存条件保存条件保存条件 :::::\xa0\xa0\xa0\xa0Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.Store at -20 °°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °°C.C.
PubMed :\xa0\xa0PubMedPubMed :\xa0\xa0PubMedPubMed :\xa0\xa0PubMedPubMed PubMed PubMed PubMed PubMed :::::\xa0\xa0\xa0\xa0PubMedPubMedPubMedPubMed
产品介绍:\xa0\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]产品介绍:\xa0\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]产品介绍产品介绍产品介绍产品介绍产品介绍产品介绍 :::::\xa0\xa0\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]\xa0Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function:Function:Function:Function:Function:Function:Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

Subcellular Location:Subcellular Location:Subcellular Location:Subcellular Location:Subcellular Location:Subcellular Location:Subcellular Location:
Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Tissue Specificity:Tissue Specificity:Tissue Specificity:Tissue Specificity:Tissue Specificity:Tissue Specificity:Tissue Specificity:
Ubiquitous.Ubiquitous.Ubiquitous.Ubiquitous.Ubiquitous.Ubiquitous.

Post-translational modifications:Post-translational modifications:Post-translational modifications:Post-translational modifications:Post-translational modifications:Post-translational modifications:Post-translational modifications:
Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.

Similarity:Similarity:Similarity:Similarity:Similarity:Similarity:Similarity:
Contains 1 histone H2A domain.Contains 1 histone H2A domain.Contains 1 histone H2A domain.Contains 1 histone H2A domain.Contains 1 histone H2A domain.Contains 1 histone H2A domain.
Contains 1 Macro domain.Contains 1 Macro domain.Contains 1 Macro domain.Contains 1 Macro domain.Contains 1 Macro domain.Contains 1 Macro domain.

SWISS:SWISS:SWISS:SWISS:SWISS:SWISS:SWISS:
O75367O75367O75367O75367O75367O75367

Gene ID:Gene ID:Gene ID:Gene ID:Gene ID:Gene ID:Gene ID:
955595559555955595559555

Important Note:Important Note:Important Note:Important Note:Important Note:Important Note:Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.