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【Molecular Wt.】52 kDa
【Molecular Wt.】52 kDa【Description】Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign and improperly folded proteins by targeting them for proteosome degradation. UBA3 (ubiquitin-like modifier activating enzyme 3), also known as NEDD8-activating enzyme E1 catalytic subunit or UBE1C (ubiquitin-activating enzyme E1C), is a 463 amino acid protein belonging to the ubiquitin-activating E1 family and UBA3 subfamily. Ubiquitously expressed, UBA3 acts as an activator to NEDD8, a ubiquitin-like protein, thus regulating cell division, signaling and embryogenesis. UBA3 exists as two isoforms due to alternative splicing events.
【Description】Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign and improperly folded proteins by targeting them for proteosome degradation. UBA3 (ubiquitin-like modifier activating enzyme 3), also known as NEDD8-activating enzyme E1 catalytic subunit or UBE1C (ubiquitin-activating enzyme E1C), is a 463 amino acid protein belonging to the ubiquitin-activating E1 family and UBA3 subfamily. Ubiquitously expressed, UBA3 acts as an activator to NEDD8, a ubiquitin-like protein, thus regulating cell division, signaling and embryogenesis. UBA3 exists as two isoforms due to alternative splicing events.【Species Reactivity】Human;Mouse;Rat
【Species Reactivity】Human;Mouse;Rat【Tested applications】WB;ICC;IHC;FC
【Tested applications】WB;ICC;IHC;FC【Antibody type】Rabbit polyclonal Antibody
【Antibody type】Rabbit polyclonal Antibody【Immunogen】Recombinant protein
【Immunogen】Recombinant protein【Positive control】Human liver tissue lysate, A431, HUVEC, SH-SY5Y, rat brain tissue, human pancreas tissue, mouse testis tissue.
【Positive control】Human liver tissue lysate, A431, HUVEC, SH-SY5Y, rat brain tissue, human pancreas tissue, mouse testis tissue.【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】DKFZp566J164 antibody
EC 6.3.2. antibody
hUba3 antibody
MGC22384 antibody
NEDD8 activating enzyme E1 catalytic subunit antibody
NEDD8 activating enzyme E1C antibody
Nedd8 activating enzyme hUba3 antibody
NEDD8-activating enzyme E1 catalytic subunit antibody
NEDD8-activating enzyme E1C antibody
uba3 antibody
UBA3 ubiquitin activating enzyme E1 homolog antibody
UBA3_HUMAN antibody
UBE1C antibody
Ubiquitin activating enzyme 3 antibody
Ubiquitin activating enzyme E1C antibody
Ubiquitin-activating enzyme 3 antibody
Ubiquitin-activating enzyme E1C antibody
Ubiquitin-like modifier-activating enzyme 3 antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃after thawing. Aliquot store at -20℃or -80℃Avoid repeated freeze / thaw cycles.
【Stroage】Store at +4℃after thawing. Aliquot store at -20℃or -80℃Avoid repeated freeze / thaw cycles.【Stroage Buffer】1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG
【Isotype】IgG【Purity】Protein A purified.
【Purity】Protein A purified.【Subcellular location】Nucleus. Cytoplasm.
【Subcellular location】Nucleus. Cytoplasm.【Background References】1. Coleman KE et al. SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function. Elife 6:N/A (2017).
2. Xu J et al. The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics 14:499-509 (2015).
【DatasheetURL】http://www.huabio.com/upload/R1706-14.pdf
【DatasheetURL】http://www.huabio.com/upload/R1706-14.pdf【Uniprot ID】Q8TBC4(Human) Q8C878(Mouse) Q99MI7(Rat)
【Uniprot ID】Q8TBC4(Human) Q8C878(Mouse) Q99MI7(Rat)【Raised in】Rabbit
【Raised in】Rabbit【Clone No.】
【Clone No.】
