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【Molecular Wt.】265 kDa
【Molecular Wt.】265 kDa【Description】Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.
【Description】Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.【Species Reactivity】Human;Mouse;Rat
【Species Reactivity】Human;Mouse;Rat【Tested applications】WB;IHC
【Tested applications】WB;IHC【Antibody type】Recombinant Rabbit monoclonal Antibody
【Antibody type】Recombinant Rabbit monoclonal Antibody【Immunogen】recombinant protein
【Immunogen】recombinant protein【Positive control】Human kidney tissue, mouse placenta tissue, mouse kidney lysates.
【Positive control】Human kidney tissue, mouse placenta tissue, mouse kidney lysates.【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】ACAC antibody
ACACA antibody
ACACA_HUMAN antibody
ACACB antibody
ACC alpha antibody
ACC antibody
ACC beta antibody
ACC-alpha antibody
ACC1 antibody
ACC2 antibody
ACCA antibody
ACCB antibody
Acetyl CoA carboxylase 1 antibody
Acetyl CoA carboxylase 2 antibody
Acetyl CoA carboxylase alpha antibody
Acetyl CoA carboxylase beta antibody
Acetyl Coenzyme A carboxylase alpha antibody
Acetyl Coenzyme A carboxylase beta antibody
Biotin carboxylase antibody
COA1 antibody
COA2 antibody
HACC275 antibody
OTTHUMP00000164069 antibody
OTTHUMP00000164070 antibody
OTTHUMP00000164076 antibody
OTTHUMP00000240532 antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG
【Isotype】IgG【Purity】Protein A purified.
【Purity】Protein A purified.【Subcellular location】Cytoplasm.
【Subcellular location】Cytoplasm.【Background References】1. Tiwari M et al. Loss of Caspase-2-dependent Apoptosis Induces Autophagy after Mitochondrial Oxidative Stress in Primary Cultures of Young Adult Cortical Neurons. J Biol Chem 286:8493-506 (2011).
2. Chang NW et al. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochim Biophys Acta 1812:558-64 (2011).
【DatasheetURL】http://www.huabio.com/upload/ET1609-77.pdf
【DatasheetURL】http://www.huabio.com/upload/ET1609-77.pdf【Uniprot ID】Q13085(Human) Q5SWU9(Mouse) P11497(Rat)
【Uniprot ID】Q13085(Human) Q5SWU9(Mouse) P11497(Rat)【Raised in】Rabbit
【Raised in】Rabbit【Clone No.】ST53-08
【Clone No.】ST53-08
