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【Molecular Wt.】60 kDa
【Molecular Wt.】60 kDa【Description】This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Studies have shown tyrosinase to be a very specific marker for melanomas, not cross reacting with any other tumors or normal tissues tested Other studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, neither tyrosinase or MART-1 discriminates between activated or resting melanocytes. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45.
【Description】This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Studies have shown tyrosinase to be a very specific marker for melanomas, not cross reacting with any other tumors or normal tissues tested Other studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, neither tyrosinase or MART-1 discriminates between activated or resting melanocytes. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45.【Species Reactivity】Human;Mouse
【Species Reactivity】Human;Mouse【Tested applications】WB;ICC;IHC;FC
【Tested applications】WB;ICC;IHC;FC【Antibody type】Mouse monoclonal Antibody
【Antibody type】Mouse monoclonal Antibody【Immunogen】Peptide linked to KLH
【Immunogen】Peptide linked to KLH【Positive control】Melanoma cells lysates, B16F1, human melanoma tissue.
【Positive control】Melanoma cells lysates, B16F1, human melanoma tissue.【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】ATN antibody
CMM8 antibody
LB24 AB antibody
LB24-AB antibody
Monophenol monooxygenase antibody
OCA1 antibody
OCA1A antibody
OCAIA antibody
Oculocutaneous albinism IA antibody
SHEP3 antibody
SK29 AB antibody
SK29-AB antibody
Tumor rejection antigen AB antibody
TYR antibody
TYRO_HUMAN antibody
tyrosinase (oculocutaneous albinism IA) antibody
Tyrosinase antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -391℃. Avoid repeated freeze / thaw cycles.
【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -391℃. Avoid repeated freeze / thaw cycles.【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG1
【Isotype】IgG1【Purity】Protein A purified.
【Purity】Protein A purified.【Subcellular location】Membrane.
【Subcellular location】Membrane.【Background References】1. Liu W et al. Hepatic epithelioid angiomyolipoma is a rare and potentially severe but treatable tumor: A report of three cases and review of the literature. Oncol Lett 11:3669-3675 (2016).
2. Turajlic S et al. Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition. Ann Oncol 25:959-67 (2014).
【DatasheetURL】http://www.huabio.com/upload/M1701-2.pdf
【DatasheetURL】http://www.huabio.com/upload/M1701-2.pdf【Uniprot ID】P14679(Human) Q2TA50(Mouse)
【Uniprot ID】P14679(Human) Q2TA50(Mouse)【Raised in】Mouse
【Raised in】Mouse【Clone No.】C2-B5
【Clone No.】C2-B5
