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【Molecular Wt.】41 kDa
【Molecular Wt.】41 kDa【Description】Members of the C-X-C or α chemokine family are characterized by a pair of cysteine residues separated by a single amino acid and primarily function as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins and include proteins such as IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). C-X-C chemokine receptor type 7 (CXCR-7), also known as RDC-1, is a 362 amino acid receptor for SDF-1. Initially identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor. CXCR-7, with CSCR-4, also acts as a coreceptor for human immunodeficiency viruses (HIV). Highly expressed in monocytes, B-cells and basophils, and highly active in various biological processes, including cell growth, cell adhesion and tumor growth, CXCR-7 may play a role in tumorigenesis.
【Description】Members of the C-X-C or α chemokine family are characterized by a pair of cysteine residues separated by a single amino acid and primarily function as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins and include proteins such as IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). C-X-C chemokine receptor type 7 (CXCR-7), also known as RDC-1, is a 362 amino acid receptor for SDF-1. Initially identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor. CXCR-7, with CSCR-4, also acts as a coreceptor for human immunodeficiency viruses (HIV). Highly expressed in monocytes, B-cells and basophils, and highly active in various biological processes, including cell growth, cell adhesion and tumor growth, CXCR-7 may play a role in tumorigenesis.【Species Reactivity】Human;Mouse;Rat
【Species Reactivity】Human;Mouse;Rat【Tested applications】WB;FC
【Tested applications】WB;FC【Antibody type】Recombinant Rabbit monoclonal Antibody
【Antibody type】Recombinant Rabbit monoclonal Antibody【Immunogen】recombinant protein
【Immunogen】recombinant protein【Positive control】PC-3M.
【Positive control】PC-3M.【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】ACKR3 antibody
atypical chemokine receptor 3 antibody
C X C chemokine receptor type 7 antibody
C-X-C chemokine receptor type 7 antibody
Chemokine (C-X-C motif) receptor 7 antibody
Chemokine C X C motif receptor 7 antibody
Chemokine orphan receptor 1 antibody
CMKOR1 antibody
CXC R7 antibody
CXC-R7 antibody
CXCR 7 antibody
CXCR-7 antibody
CXCR7 antibody
CXCR7_HUMAN antibody
G protein coupled receptor 159 antibody
G protein coupled receptor antibody
G protein coupled receptor RDC1 homolog antibody
G-protein coupled receptor 159 antibody
G-protein coupled receptor RDC1 homolog antibody
GPR159 antibody
GPRN1 antibody
RDC 1 antibody
RDC-1 antibody
RDC1 antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG
【Isotype】IgG【Purity】Protein A purified.
【Purity】Protein A purified.【Subcellular location】Cell membrane, Cytoplasm.
【Subcellular location】Cell membrane, Cytoplasm.【Background References】1. Melo Rde C et al. CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12. PLoS One 9:e85926 (2014).
2. Roy I et al. CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One 9:e90400 (2014).
【DatasheetURL】http://www.huabio.com/upload/ET1611-3.pdf
【DatasheetURL】http://www.huabio.com/upload/ET1611-3.pdf【Uniprot ID】P25106(Human) P56485(Mouse) O89039(Rat)
【Uniprot ID】P25106(Human) P56485(Mouse) O89039(Rat)【Raised in】Rabbit
【Raised in】Rabbit【Clone No.】SN65-09
【Clone No.】SN65-09
