\n 本公司提供科研TSHR促甲状腺素受体抗体TSHR促甲状腺素受体抗体，抗体质量可靠，订购TSHR促甲状腺素受体抗体TSHR促甲状腺素受体抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：促甲状腺素受体抗体促甲状腺素受体抗体
英文名称：Anti-TSHRAnti-TSHR
货号：bs-0460R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 84kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.Subunit : Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.Subcellular Location : Cell membrane; Multi-pass membrane protein.Tissue Specificity : Expressed in the thyroid.Similarity : Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 7 LRR (leucine-rich) repeats.TSHR是垂体前叶嗜碱细胞分泌的一种糖蛋白，直接作用于甲状腺，并能影响其结构功能。该抗体主要用于垂体肿瘤功能性分类的研究。