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\xa0\xa0MEK2/MAPKK2 Antibody\xa0MEK2/MAPKK2 Antibody\xa0MEK2/MAPKK2 Antibody
\xa0Cat#：Cat#：PL0304003
\xa0Isotype:Isotype:Rabbit Polyclonal IgG
\xa0Immunogen：Immunogen：Peptide derived from human MAPKK2. \xa0
\xa0Purification:\xa0Purification:\xa0Immunogen affinity purified

Storage Buffer:\xa0Storage Buffer:\xa0PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：Background：The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.\xa0Alternate Names：Alternate Names：Cardiofaciocutaneous syndrome; CFC syndrome; Dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K 2; map2k2; MAPK / ERK kinase 2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; Microtubule Associated Protein Kinase Kinase 2; Mitogen activated protein kinase kinase 2; Mitogen activated protein kinase kinase 2 p45; MKK 2; MKK2; MP2K2_HUMAN; OTTHUMP00000165826; OTTHUMP00000165827; PRKMK 2; PRKMK2 V.\xa0
\xa0Specificity Reaction：Specificity Reaction：Hu, Mo, Rat, Chi\xa0Application Notes:Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100\xa0IHC: 1:100-500 IF: 1:100-500\xa0Storage ：Storage ：Store at –20oC for one year. Avoid repeated freeze-thaw cycles. At 4oC for 2-3 weeks after reconstituted.\xa0
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.This product for research use only, not for use in humans, therapeutic or diagnostic procedures.This product for research use only, not for use in humans, therapeutic or diagnostic procedures.\xa0PLlabs公司PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素（FITC、PE、 \xa0CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体，欢迎大家咨询订购。

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