\n

\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

英文名称	GLUR2
中文名称	谷氨酸受体2抗体
别\xa0\xa0\xa0\xa0名	Ionotropic Glutamate receptor 2; Gria2; Glur-2; GluR-B; Glur2; GluR-2; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA receptor subunit ; AMPA-selective glutamate receptor 2; AMPA 2; AMPA 2; AMPA selective glutamate receptor 2; AMPA-selective glutamate receptor 2; AMPA2; GluA2; GLUR 2; GluR B; GluR K2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic AMPA 2; Glutamate receptor ionotropic; Gria2; GRIA2_HUMAN; HBGR2.\xa0\xa0

\t\t\t\t\t\t英文名称\t\t\tGLUR2\t\t\t\t\t\t\t中文名称\t\t\t谷氨酸受体2抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tIonotropic Glutamate receptor 2; Gria2; Glur-2; GluR-B; Glur2; GluR-2; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA receptor subunit ; AMPA-selective glutamate receptor 2; AMPA 2; AMPA 2; AMPA selective glutamate receptor 2; AMPA-selective glutamate receptor 2; AMPA2; GluA2; GLUR 2; GluR B; GluR K2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic AMPA 2; Glutamate receptor ionotropic; Gria2; GRIA2_HUMAN; HBGR2.\xa0\xa0\t\t\t\t\t\t\t\t英文名称\t\t\tGLUR2\t\t\t\t\t英文名称英文名称\t\t\tGLUR2GLUR2\t\t\t\t\t\t\t中文名称\t\t\t谷氨酸受体2抗体\t\t\t\t\t中文名称中文名称\t\t\t谷氨酸受体2抗体谷氨酸受体2抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tIonotropic Glutamate receptor 2; Gria2; Glur-2; GluR-B; Glur2; GluR-2; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA receptor subunit ; AMPA-selective glutamate receptor 2; AMPA 2; AMPA 2; AMPA selective glutamate receptor 2; AMPA-selective glutamate receptor 2; AMPA2; GluA2; GLUR 2; GluR B; GluR K2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic AMPA 2; Glutamate receptor ionotropic; Gria2; GRIA2_HUMAN; HBGR2.\xa0\xa0\t\t\t\t\t别\xa0\xa0\xa0\xa0名别\xa0\xa0\xa0\xa0名\t\t\tIonotropic Glutamate receptor 2; Gria2; Glur-2; GluR-B; Glur2; GluR-2; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA receptor subunit ; AMPA-selective glutamate receptor 2; AMPA 2; AMPA 2; AMPA selective glutamate receptor 2; AMPA-selective glutamate receptor 2; AMPA2; GluA2; GLUR 2; GluR B; GluR K2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic AMPA 2; Glutamate receptor ionotropic; Gria2; GRIA2_HUMAN; HBGR2.\xa0\xa0Ionotropic Glutamate receptor 2; Gria2; Glur-2; GluR-B; Glur2; GluR-2; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA receptor subunit ; AMPA-selective glutamate receptor 2; AMPA 2; AMPA 2; AMPA selective glutamate receptor 2; AMPA-selective glutamate receptor 2; AMPA2; GluA2; GLUR 2; GluR B; GluR K2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic AMPA 2; Glutamate receptor ionotropic; Gria2; GRIA2_HUMAN; HBGR2.\xa0\xa0\t\t\t

\xa0

\xa0

\xa0

\xa0

\xa0

\xa0\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

研究领域	细胞生物\xa0\xa0免疫学\xa0\xa0神经生物学\xa0\xa0信号转导\xa0\xa0细胞膜受体\xa0\xa0
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Dog,\xa0)
产品应用	WB=1:500-2000\xa0ELISA=1:5000-10000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1μg /test\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复） \t\t\tnot yet tested in other applications. \t\t\toptimal dilutions/concentrations should be determined by the end user.
分\xa0子\xa0量	97kDa
细胞定位	细胞浆\xa0细胞膜\xa0
性\xa0\xa0\xa0\xa0状	Liquid
浓\xa0\xa0\xa0\xa0度	1mg/ml
免\xa0疫\xa0原	KLH conjugated Synthesised phosphopeptide derived from human Gria2 around the phosphorylation site of Ser880:151-250/883\xa0<Extracellular>
亚\xa0\xa0\xa0\xa0型	IgG
纯化方法	affinity purified by Protein A
储\xa0存\xa0液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. \t\t\t \t\t\tFunction: \t\t\tIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. \t\t\t \t\t\tSubunit: \t\t\tHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5. \t\t\t \t\t\tSubcellular Location: \t\t\tCell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. \t\t\t \t\t\tSimilarity: \t\t\tBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. \t\t\t \t\t\tSWISS: \t\t\tP42262 \t\t\t \t\t\tGene ID: \t\t\t2891 \t\t\t \t\t\tDatabase links:\t\t\t Entrez Gene: 2891\xa0Human \t\t\t Entrez Gene: 14800\xa0Mouse \t\t\t Entrez Gene: 29627\xa0Rat \t\t\t Omim: 138247\xa0Human \t\t\t SwissProt: P42262\xa0Human \t\t\t SwissProt: P23819\xa0Mouse \t\t\t SwissProt: P19491\xa0Rat \t\t\t Unigene: 32763\xa0Human \t\t\t Unigene: 220224\xa0Mouse \t\t\t Unigene: 91361\xa0Rat \t\t\t \t\t\t \t\t\tImportant Note: \t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

\t\t\t\t\t\t研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0神经生物学\xa0\xa0信号转导\xa0\xa0细胞膜受体\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Dog,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1μg /test\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t97kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞浆\xa0细胞膜\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated Synthesised phosphopeptide derived from human Gria2 around the phosphorylation site of Ser880:151-250/883\xa0<Extracellular>\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\t\t\t产品介绍\t\t\tGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
\t\t\t
\t\t\tFunction:
\t\t\tIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
\t\t\t
\t\t\tSubunit:
\t\t\tHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tCell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
\t\t\t
\t\t\tSWISS:
\t\t\tP42262
\t\t\t
\t\t\tGene ID:
\t\t\t2891
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 2891\xa0Human

\t\t\t

Entrez Gene: 14800\xa0Mouse

\t\t\t

Entrez Gene: 29627\xa0Rat

\t\t\t

Omim: 138247\xa0Human

\t\t\t

SwissProt: P42262\xa0Human

\t\t\t

SwissProt: P23819\xa0Mouse

\t\t\t

SwissProt: P19491\xa0Rat

\t\t\t

Unigene: 32763\xa0Human

\t\t\t

Unigene: 220224\xa0Mouse

\t\t\t

Unigene: 91361\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t\t\t\t\t\t研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0神经生物学\xa0\xa0信号转导\xa0\xa0细胞膜受体\xa0\xa0\t\t\t\t\t研究领域研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0神经生物学\xa0\xa0信号转导\xa0\xa0细胞膜受体\xa0\xa0细胞生物\xa0\xa0免疫学\xa0\xa0神经生物学\xa0\xa0信号转导\xa0\xa0细胞膜受体\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t抗体来源抗体来源\t\t\tRabbitRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t克隆类型克隆类型\t\t\tPolyclonalPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Dog,\xa0)\t\t\t\t\t交叉反应交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Dog,\xa0)Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Dog,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1μg /test\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t产品应用产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1μg /test\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.WB=1:500-2000\xa0ELISA=1:5000-10000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1μg /test\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t97kDa\t\t\t\t\t分\xa0子\xa0量分\xa0子\xa0量\t\t\t97kDa97kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞浆\xa0细胞膜\xa0\t\t\t\t\t细胞定位细胞定位\t\t\t细胞浆\xa0细胞膜\xa0细胞浆\xa0细胞膜\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t性\xa0\xa0\xa0\xa0状性\xa0\xa0\xa0\xa0状\t\t\tLiquidLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t浓\xa0\xa0\xa0\xa0度浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated Synthesised phosphopeptide derived from human Gria2 around the phosphorylation site of Ser880:151-250/883\xa0<Extracellular>\t\t\t\t\t免\xa0疫\xa0原免\xa0疫\xa0原\t\t\tKLH conjugated Synthesised phosphopeptide derived from human Gria2 around the phosphorylation site of Ser880:151-250/883\xa0<Extracellular>KLH conjugated Synthesised phosphopeptide derived from human Gria2 around the phosphorylation site of Ser880:151-250/883\xa0\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t亚\xa0\xa0\xa0\xa0型亚\xa0\xa0\xa0\xa0型\t\t\tIgGIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t纯化方法纯化方法\t\t\taffinity purified by Protein Aaffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t储\xa0存\xa0液储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t保存条件保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\tPubMedPubMed\t\t\tPubMedPubMedPubMed\t\t\t\t\t\t\t产品介绍\t\t\tGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
\t\t\t
\t\t\tFunction:
\t\t\tIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
\t\t\t
\t\t\tSubunit:
\t\t\tHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tCell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
\t\t\t
\t\t\tSWISS:
\t\t\tP42262
\t\t\t
\t\t\tGene ID:
\t\t\t2891
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 2891\xa0Human

\t\t\t

Entrez Gene: 14800\xa0Mouse

\t\t\t

Entrez Gene: 29627\xa0Rat

\t\t\t

Omim: 138247\xa0Human

\t\t\t

SwissProt: P42262\xa0Human

\t\t\t

SwissProt: P23819\xa0Mouse

\t\t\t

SwissProt: P19491\xa0Rat

\t\t\t

Unigene: 32763\xa0Human

\t\t\t

Unigene: 220224\xa0Mouse

\t\t\t

Unigene: 91361\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t\t\t产品介绍产品介绍\t\t\tGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
\t\t\t
\t\t\tFunction:
\t\t\tIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
\t\t\t
\t\t\tSubunit:
\t\t\tHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tCell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
\t\t\t
\t\t\tSWISS:
\t\t\tP42262
\t\t\t
\t\t\tGene ID:
\t\t\t2891
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 2891\xa0Human

\t\t\t

Entrez Gene: 14800\xa0Mouse

\t\t\t

Entrez Gene: 29627\xa0Rat

\t\t\t

Omim: 138247\xa0Human

\t\t\t

SwissProt: P42262\xa0Human

\t\t\t

SwissProt: P23819\xa0Mouse

\t\t\t

SwissProt: P19491\xa0Rat

\t\t\t

Unigene: 32763\xa0Human

\t\t\t

Unigene: 220224\xa0Mouse

\t\t\t

Unigene: 91361\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
\t\t\t
\t\t\tFunction:
\t\t\tIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
\t\t\t
\t\t\tSubunit:
\t\t\tHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tCell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
\t\t\t
\t\t\tSWISS:
\t\t\tP42262
\t\t\t
\t\t\tGene ID:
\t\t\t2891
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 2891\xa0Human

Entrez Gene: 2891Entrez Gene: 2891\xa0Human\t\t\t

Entrez Gene: 14800\xa0Mouse

Entrez Gene: 14800Entrez Gene: 14800\xa0Mouse\t\t\t

Entrez Gene: 29627\xa0Rat

Entrez Gene: 29627Entrez Gene: 29627\xa0Rat\t\t\t

Omim: 138247\xa0Human

Omim: 138247Omim: 138247\xa0Human\t\t\t

SwissProt: P42262\xa0Human

SwissProt: P42262SwissProt: P42262\xa0Human\t\t\t

SwissProt: P23819\xa0Mouse

SwissProt: P23819SwissProt: P23819\xa0Mouse\t\t\t

SwissProt: P19491\xa0Rat

SwissProt: P19491SwissProt: P19491\xa0Rat\t\t\t

Unigene: 32763\xa0Human

Unigene: 32763Unigene: 32763\xa0Human\t\t\t

Unigene: 220224\xa0Mouse

Unigene: 220224Unigene: 220224\xa0Mouse\t\t\t

Unigene: 91361\xa0Rat

Unigene: 91361Unigene: 91361\xa0Rat\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t

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