\n

\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

英文名称	CD95/FAS
中文名称	载脂蛋白1抗体
别\xa0\xa0\xa0\xa0名	Apo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.\xa0\xa0

\t\t\t\t\t\t英文名称\t\t\tCD95/FAS\t\t\t\t\t\t\t中文名称\t\t\t载脂蛋白1抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tApo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.\xa0\xa0\t\t\t\t\t\t\t\t英文名称\t\t\tCD95/FAS\t\t\t\t\t英文名称英文名称\t\t\tCD95/FASCD95/FAS\t\t\t\t\t\t\t中文名称\t\t\t载脂蛋白1抗体\t\t\t\t\t中文名称中文名称\t\t\t载脂蛋白1抗体载脂蛋白1抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tApo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.\xa0\xa0\t\t\t\t\t别\xa0\xa0\xa0\xa0名别\xa0\xa0\xa0\xa0名\t\t\tApo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.\xa0\xa0Apo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.\xa0\xa0\t\t\t

\xa0

\xa0

\xa0

\xa0

\xa0

\xa0\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

研究领域	细胞生物\xa0\xa0免疫学\xa0\xa0细胞凋亡\xa0\xa0
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Pig,\xa0)
产品应用	WB=1:500-2000\xa0ELISA=1:5000-10000\xa0Flow-Cyt=1μg/Test\xa0 \t\t\tnot yet tested in other applications. \t\t\toptimal dilutions/concentrations should be determined by the end user.
分\xa0子\xa0量	34kDa
细胞定位	细胞膜\xa0分泌型蛋白\xa0
性\xa0\xa0\xa0\xa0状	Liquid
浓\xa0\xa0\xa0\xa0度	1mg/ml
免\xa0疫\xa0原	KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335\xa0<Extracellular>
亚\xa0\xa0\xa0\xa0型	IgG
纯化方法	affinity purified by Protein A
储\xa0存\xa0液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). \t\t\t \t\t\tFunction: \t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). \t\t\t \t\t\tSubunit: \t\t\tBinds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. \t\t\t \t\t\tSubcellular Location: \t\t\tIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted. \t\t\t \t\t\tTissue Specificity: \t\t\tIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. \t\t\t \t\t\tPost-translational modifications: \t\t\tN- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. \t\t\t \t\t\tDISEASE: \t\t\tDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. \t\t\t \t\t\tSimilarity: \t\t\tContains 1 death domain. \t\t\tContains 3 TNFR-Cys repeats. \t\t\t \t\t\tSWISS: \t\t\tP25445 \t\t\t \t\t\tGene ID: \t\t\t355 \t\t\t \t\t\tDatabase links:\t\t\t Entrez Gene: 355\xa0Human \t\t\t Entrez Gene: 14102\xa0Mouse \t\t\t Entrez Gene: 246097\xa0Rat \t\t\t Omim: 134637\xa0Human \t\t\t SwissProt: P25445\xa0Human \t\t\t SwissProt: P25446\xa0Mouse \t\t\t SwissProt: Q63199\xa0Rat \t\t\t Unigene: 244139\xa0Human \t\t\t Unigene: 1626\xa0Mouse \t\t\t Unigene: 162521\xa0Rat \t\t\t \t\t\t \t\t\tImportant Note: \t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

\t\t\t\t\t\t研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0细胞凋亡\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Pig,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0Flow-Cyt=1μg/Test\xa0
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t34kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞膜\xa0分泌型蛋白\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335\xa0<Extracellular>\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\t\t\t产品介绍\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tFunction:
\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tSubunit:
\t\t\tBinds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.
\t\t\t
\t\t\tTissue Specificity:
\t\t\tIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tN- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
\t\t\t
\t\t\tDISEASE:
\t\t\tDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
\t\t\t
\t\t\tSimilarity:
\t\t\tContains 1 death domain.
\t\t\tContains 3 TNFR-Cys repeats.
\t\t\t
\t\t\tSWISS:
\t\t\tP25445
\t\t\t
\t\t\tGene ID:
\t\t\t355
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 355\xa0Human

\t\t\t

Entrez Gene: 14102\xa0Mouse

\t\t\t

Entrez Gene: 246097\xa0Rat

\t\t\t

Omim: 134637\xa0Human

\t\t\t

SwissProt: P25445\xa0Human

\t\t\t

SwissProt: P25446\xa0Mouse

\t\t\t

SwissProt: Q63199\xa0Rat

\t\t\t

Unigene: 244139\xa0Human

\t\t\t

Unigene: 1626\xa0Mouse

\t\t\t

Unigene: 162521\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications\t\t\t\t\t\t\t\t研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0细胞凋亡\xa0\xa0\t\t\t\t\t研究领域研究领域\t\t\t细胞生物\xa0\xa0免疫学\xa0\xa0细胞凋亡\xa0\xa0细胞生物细胞生物\xa0\xa0免疫学免疫学\xa0\xa0细胞凋亡细胞凋亡\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t抗体来源抗体来源\t\t\tRabbitRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t克隆类型克隆类型\t\t\tPolyclonalPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Pig,\xa0)\t\t\t\t\t交叉反应交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Pig,\xa0)Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Pig,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0Flow-Cyt=1μg/Test\xa0
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t产品应用产品应用\t\t\tWB=1:500-2000\xa0ELISA=1:5000-10000\xa0Flow-Cyt=1μg/Test\xa0
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.WB=1:500-2000\xa0ELISA=1:5000-10000\xa0Flow-Cyt=1μg/Test\xa0
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t34kDa\t\t\t\t\t分\xa0子\xa0量分\xa0子\xa0量\t\t\t34kDa34kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞膜\xa0分泌型蛋白\xa0\t\t\t\t\t细胞定位细胞定位\t\t\t细胞膜\xa0分泌型蛋白\xa0细胞膜\xa0分泌型蛋白\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t性\xa0\xa0\xa0\xa0状性\xa0\xa0\xa0\xa0状\t\t\tLiquidLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t浓\xa0\xa0\xa0\xa0度浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335\xa0<Extracellular>\t\t\t\t\t免\xa0疫\xa0原免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335\xa0<Extracellular>KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335\xa0\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t亚\xa0\xa0\xa0\xa0型亚\xa0\xa0\xa0\xa0型\t\t\tIgGIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t纯化方法纯化方法\t\t\taffinity purified by Protein Aaffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t储\xa0存\xa0液储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t保存条件保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\tPubMedPubMed\t\t\tPubMedPubMedPubMed\t\t\t\t\t\t\t产品介绍\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tFunction:
\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tSubunit:
\t\t\tBinds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.
\t\t\t
\t\t\tTissue Specificity:
\t\t\tIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tN- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
\t\t\t
\t\t\tDISEASE:
\t\t\tDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
\t\t\t
\t\t\tSimilarity:
\t\t\tContains 1 death domain.
\t\t\tContains 3 TNFR-Cys repeats.
\t\t\t
\t\t\tSWISS:
\t\t\tP25445
\t\t\t
\t\t\tGene ID:
\t\t\t355
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 355\xa0Human

\t\t\t

Entrez Gene: 14102\xa0Mouse

\t\t\t

Entrez Gene: 246097\xa0Rat

\t\t\t

Omim: 134637\xa0Human

\t\t\t

SwissProt: P25445\xa0Human

\t\t\t

SwissProt: P25446\xa0Mouse

\t\t\t

SwissProt: Q63199\xa0Rat

\t\t\t

Unigene: 244139\xa0Human

\t\t\t

Unigene: 1626\xa0Mouse

\t\t\t

Unigene: 162521\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications\t\t\t\t\t产品介绍产品介绍\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tFunction:
\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tSubunit:
\t\t\tBinds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.
\t\t\t
\t\t\tTissue Specificity:
\t\t\tIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tN- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
\t\t\t
\t\t\tDISEASE:
\t\t\tDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
\t\t\t
\t\t\tSimilarity:
\t\t\tContains 1 death domain.
\t\t\tContains 3 TNFR-Cys repeats.
\t\t\t
\t\t\tSWISS:
\t\t\tP25445
\t\t\t
\t\t\tGene ID:
\t\t\t355
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 355\xa0Human

\t\t\t

Entrez Gene: 14102\xa0Mouse

\t\t\t

Entrez Gene: 246097\xa0Rat

\t\t\t

Omim: 134637\xa0Human

\t\t\t

SwissProt: P25445\xa0Human

\t\t\t

SwissProt: P25446\xa0Mouse

\t\t\t

SwissProt: Q63199\xa0Rat

\t\t\t

Unigene: 244139\xa0Human

\t\t\t

Unigene: 1626\xa0Mouse

\t\t\t

Unigene: 162521\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applicationsReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tFunction:
\t\t\tReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
\t\t\t
\t\t\tSubunit:
\t\t\tBinds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.
\t\t\t
\t\t\tTissue Specificity:
\t\t\tIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tN- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
\t\t\t
\t\t\tDISEASE:
\t\t\tDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
\t\t\t
\t\t\tSimilarity:
\t\t\tContains 1 death domain.
\t\t\tContains 3 TNFR-Cys repeats.
\t\t\t
\t\t\tSWISS:
\t\t\tP25445
\t\t\t
\t\t\tGene ID:
\t\t\t355
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 355\xa0Human

Entrez Gene: 355Entrez Gene: 355\xa0Human\t\t\t

Entrez Gene: 14102\xa0Mouse

Entrez Gene: 14102Entrez Gene: 14102\xa0Mouse\t\t\t

Entrez Gene: 246097\xa0Rat

Entrez Gene: 246097Entrez Gene: 246097\xa0Rat\t\t\t

Omim: 134637\xa0Human

Omim: 134637Omim: 134637\xa0Human\t\t\t

SwissProt: P25445\xa0Human

SwissProt: P25445SwissProt: P25445\xa0Human\t\t\t

SwissProt: P25446\xa0Mouse

SwissProt: P25446SwissProt: P25446\xa0Mouse\t\t\t

SwissProt: Q63199\xa0Rat

SwissProt: Q63199SwissProt: Q63199\xa0Rat\t\t\t

Unigene: 244139\xa0Human

Unigene: 244139Unigene: 244139\xa0Human\t\t\t

Unigene: 1626\xa0Mouse

Unigene: 1626Unigene: 1626\xa0Mouse\t\t\t

Unigene: 162521\xa0Rat

Unigene: 162521Unigene: 162521\xa0Rat\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications\t\t\t

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