\n

\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

英文名称	Progesterone Receptor
中文名称	孕激素受体抗体
别\xa0\xa0\xa0\xa0名	NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.

\t\t\t\t\t\t英文名称\t\t\tProgesterone Receptor\t\t\t\t\t\t\t中文名称\t\t\t孕激素受体抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tNR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.\t\t\t\t\t\t\t\t英文名称\t\t\tProgesterone Receptor\t\t\t\t\t英文名称英文名称\t\t\tProgesterone ReceptorProgesterone Receptor\t\t\t\t\t\t\t中文名称\t\t\t孕激素受体抗体\t\t\t\t\t中文名称中文名称\t\t\t孕激素受体抗体孕激素受体抗体\t\t\t\t\t\t\t别\xa0\xa0\xa0\xa0名\t\t\tNR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.\t\t\t\t\t别\xa0\xa0\xa0\xa0名别\xa0\xa0\xa0\xa0名\t\t\tNR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.\t\t\t

\xa0

\xa0\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t

研究领域	肿瘤\xa0\xa0免疫学\xa0\xa0信号转导\xa0\xa0生长因子和激素\xa0\xa0肿瘤细胞生物标志物\xa0\xa0
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Rabbit,\xa0)
产品应用	WB=1:500-2000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1ug/Test\xa0ICC=1:100-500\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复） \t\t\tnot yet tested in other applications. \t\t\toptimal dilutions/concentrations should be determined by the end user.
分\xa0子\xa0量	103kDa
细胞定位	细胞核\xa0细胞浆\xa0
性\xa0\xa0\xa0\xa0状	Liquid
浓\xa0\xa0\xa0\xa0度	1mg/ml
免\xa0疫\xa0原	KLH conjugated synthetic peptide derived from human Progesterone Receptor:221-320/933\xa0
亚\xa0\xa0\xa0\xa0型	IgG
纯化方法	affinity purified by Protein A
储\xa0存\xa0液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors. \t\t\t \t\t\tFunction: \t\t\tThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. \t\t\tIsoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation. \t\t\t \t\t\tSubunit: \t\t\tInteracts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. \t\t\t \t\t\tSubcellular Location: \t\t\tNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear. \t\t\t \t\t\tPost-translational modifications: \t\t\tPhosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMa and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1. \t\t\tSumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294. \t\t\t \t\t\tSimilarity: \t\t\tBelongs to the nuclear hormone receptor family. NR3 subfamily. \t\t\tContains 1 nuclear receptor DNA-binding domain. \t\t\t \t\t\tSWISS: \t\t\tP06401 \t\t\t \t\t\tGene ID: \t\t\t5241 \t\t\t \t\t\tDatabase links:\t\t\t Entrez Gene: 5241\xa0Human \t\t\t Entrez Gene: 18667\xa0Mouse \t\t\t Entrez Gene: 100009094\xa0Rabbit \t\t\t Entrez Gene: 25154\xa0Rat \t\t\t Omim: 607311\xa0Human \t\t\t SwissProt: P06401\xa0Human \t\t\t SwissProt: Q00175\xa0Mouse \t\t\t SwissProt: P06186\xa0Rabbit \t\t\t SwissProt: Q63449\xa0Rat \t\t\t Unigene: 2905\xa0Human \t\t\t Unigene: 32405\xa0Human \t\t\t Unigene: 742403\xa0Human \t\t\t Unigene: 12798\xa0Mouse \t\t\t Unigene: 437703\xa0Mouse \t\t\t Unigene: 1947\xa0Rabbit \t\t\t Unigene: 10303\xa0Rat \t\t\t \t\t\t \t\t\tImportant Note: \t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

\t\t\t\t\t\t研究领域\t\t\t肿瘤\xa0\xa0免疫学\xa0\xa0信号转导\xa0\xa0生长因子和激素\xa0\xa0肿瘤细胞生物标志物\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Rabbit,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1ug/Test\xa0ICC=1:100-500\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t103kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞核\xa0细胞浆\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human Progesterone Receptor:221-320/933\xa0\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\t\t\t产品介绍\t\t\tEstrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
\t\t\t
\t\t\tFunction:
\t\t\tThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
\t\t\tIsoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
\t\t\t
\t\t\tSubunit:
\t\t\tInteracts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tPhosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMa and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
\t\t\tSumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the nuclear hormone receptor family. NR3 subfamily.
\t\t\tContains 1 nuclear receptor DNA-binding domain.
\t\t\t
\t\t\tSWISS:
\t\t\tP06401
\t\t\t
\t\t\tGene ID:
\t\t\t5241
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 5241\xa0Human

\t\t\t

Entrez Gene: 18667\xa0Mouse

\t\t\t

Entrez Gene: 100009094\xa0Rabbit

\t\t\t

Entrez Gene: 25154\xa0Rat

\t\t\t

Omim: 607311\xa0Human

\t\t\t

SwissProt: P06401\xa0Human

\t\t\t

SwissProt: Q00175\xa0Mouse

\t\t\t

SwissProt: P06186\xa0Rabbit

\t\t\t

SwissProt: Q63449\xa0Rat

\t\t\t

Unigene: 2905\xa0Human

\t\t\t

Unigene: 32405\xa0Human

\t\t\t

Unigene: 742403\xa0Human

\t\t\t

Unigene: 12798\xa0Mouse

\t\t\t

Unigene: 437703\xa0Mouse

\t\t\t

Unigene: 1947\xa0Rabbit

\t\t\t

Unigene: 10303\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t\t\t\t\t\t研究领域\t\t\t肿瘤\xa0\xa0免疫学\xa0\xa0信号转导\xa0\xa0生长因子和激素\xa0\xa0肿瘤细胞生物标志物\xa0\xa0\t\t\t\t\t研究领域研究领域\t\t\t肿瘤\xa0\xa0免疫学\xa0\xa0信号转导\xa0\xa0生长因子和激素\xa0\xa0肿瘤细胞生物标志物\xa0\xa0肿瘤\xa0\xa0免疫学\xa0\xa0信号转导\xa0\xa0生长因子和激素\xa0\xa0肿瘤细胞生物标志物\xa0\xa0\t\t\t\t\t\t\t抗体来源\t\t\tRabbit\t\t\t\t\t抗体来源抗体来源\t\t\tRabbitRabbit\t\t\t\t\t\t\t克隆类型\t\t\tPolyclonal\t\t\t\t\t克隆类型克隆类型\t\t\tPolyclonalPolyclonal\t\t\t\t\t\t\t交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Rabbit,\xa0)\t\t\t\t\t交叉反应交叉反应\t\t\tHuman,\xa0Mouse,\xa0Rat,\xa0 (predicted: Rabbit,\xa0)Human,\xa0Mouse,\xa0Rat,\xa0 (predicted: Rabbit,\xa0)\t\t\t\t\t\t\t产品应用\t\t\tWB=1:500-2000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1ug/Test\xa0ICC=1:100-500\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t产品应用产品应用\t\t\tWB=1:500-2000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1ug/Test\xa0ICC=1:100-500\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.WB=1:500-2000\xa0IHC-P=1:100-500\xa0IHC-F=1:100-500\xa0Flow-Cyt=1ug/Test\xa0ICC=1:100-500\xa0IF=1:100-500\xa0（石蜡切片需做抗原修复）
\t\t\tnot yet tested in other applications.
\t\t\toptimal dilutions/concentrations should be determined by the end user.\t\t\t\t\t\t\t分\xa0子\xa0量\t\t\t103kDa\t\t\t\t\t分\xa0子\xa0量分\xa0子\xa0量\t\t\t103kDa103kDa\t\t\t\t\t\t\t细胞定位\t\t\t细胞核\xa0细胞浆\xa0\t\t\t\t\t细胞定位细胞定位\t\t\t细胞核\xa0细胞浆\xa0细胞核\xa0细胞浆\xa0\t\t\t\t\t\t\t性\xa0\xa0\xa0\xa0状\t\t\tLiquid\t\t\t\t\t性\xa0\xa0\xa0\xa0状性\xa0\xa0\xa0\xa0状\t\t\tLiquidLiquid\t\t\t\t\t\t\t浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml\t\t\t\t\t浓\xa0\xa0\xa0\xa0度浓\xa0\xa0\xa0\xa0度\t\t\t1mg/ml1mg/ml\t\t\t\t\t\t\t免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human Progesterone Receptor:221-320/933\xa0\t\t\t\t\t免\xa0疫\xa0原免\xa0疫\xa0原\t\t\tKLH conjugated synthetic peptide derived from human Progesterone Receptor:221-320/933\xa0KLH conjugated synthetic peptide derived from human Progesterone Receptor:221-320/933\xa0\t\t\t\t\t\t\t亚\xa0\xa0\xa0\xa0型\t\t\tIgG\t\t\t\t\t亚\xa0\xa0\xa0\xa0型亚\xa0\xa0\xa0\xa0型\t\t\tIgGIgG\t\t\t\t\t\t\t纯化方法\t\t\taffinity purified by Protein A\t\t\t\t\t纯化方法纯化方法\t\t\taffinity purified by Protein Aaffinity purified by Protein A\t\t\t\t\t\t\t储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t储\xa0存\xa0液储\xa0存\xa0液\t\t\t0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\t\t\t\t\t\t\t保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t保存条件保存条件\t\t\tShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.\t\t\t\t\t\t\tPubMed\t\t\tPubMed\t\t\t\t\tPubMedPubMed\t\t\tPubMedPubMedPubMed\t\t\t\t\t\t\t产品介绍\t\t\tEstrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
\t\t\t
\t\t\tFunction:
\t\t\tThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
\t\t\tIsoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
\t\t\t
\t\t\tSubunit:
\t\t\tInteracts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tPhosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMa and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
\t\t\tSumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the nuclear hormone receptor family. NR3 subfamily.
\t\t\tContains 1 nuclear receptor DNA-binding domain.
\t\t\t
\t\t\tSWISS:
\t\t\tP06401
\t\t\t
\t\t\tGene ID:
\t\t\t5241
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 5241\xa0Human

\t\t\t

Entrez Gene: 18667\xa0Mouse

\t\t\t

Entrez Gene: 100009094\xa0Rabbit

\t\t\t

Entrez Gene: 25154\xa0Rat

\t\t\t

Omim: 607311\xa0Human

\t\t\t

SwissProt: P06401\xa0Human

\t\t\t

SwissProt: Q00175\xa0Mouse

\t\t\t

SwissProt: P06186\xa0Rabbit

\t\t\t

SwissProt: Q63449\xa0Rat

\t\t\t

Unigene: 2905\xa0Human

\t\t\t

Unigene: 32405\xa0Human

\t\t\t

Unigene: 742403\xa0Human

\t\t\t

Unigene: 12798\xa0Mouse

\t\t\t

Unigene: 437703\xa0Mouse

\t\t\t

Unigene: 1947\xa0Rabbit

\t\t\t

Unigene: 10303\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t\t\t产品介绍产品介绍\t\t\tEstrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
\t\t\t
\t\t\tFunction:
\t\t\tThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
\t\t\tIsoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
\t\t\t
\t\t\tSubunit:
\t\t\tInteracts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tPhosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMa and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
\t\t\tSumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the nuclear hormone receptor family. NR3 subfamily.
\t\t\tContains 1 nuclear receptor DNA-binding domain.
\t\t\t
\t\t\tSWISS:
\t\t\tP06401
\t\t\t
\t\t\tGene ID:
\t\t\t5241
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 5241\xa0Human

\t\t\t

Entrez Gene: 18667\xa0Mouse

\t\t\t

Entrez Gene: 100009094\xa0Rabbit

\t\t\t

Entrez Gene: 25154\xa0Rat

\t\t\t

Omim: 607311\xa0Human

\t\t\t

SwissProt: P06401\xa0Human

\t\t\t

SwissProt: Q00175\xa0Mouse

\t\t\t

SwissProt: P06186\xa0Rabbit

\t\t\t

SwissProt: Q63449\xa0Rat

\t\t\t

Unigene: 2905\xa0Human

\t\t\t

Unigene: 32405\xa0Human

\t\t\t

Unigene: 742403\xa0Human

\t\t\t

Unigene: 12798\xa0Mouse

\t\t\t

Unigene: 437703\xa0Mouse

\t\t\t

Unigene: 1947\xa0Rabbit

\t\t\t

Unigene: 10303\xa0Rat

\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
\t\t\t
\t\t\tFunction:
\t\t\tThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
\t\t\tIsoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
\t\t\t
\t\t\tSubunit:
\t\t\tInteracts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
\t\t\t
\t\t\tSubcellular Location:
\t\t\tNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
\t\t\t
\t\t\tPost-translational modifications:
\t\t\tPhosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMa and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
\t\t\tSumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
\t\t\t
\t\t\tSimilarity:
\t\t\tBelongs to the nuclear hormone receptor family. NR3 subfamily.
\t\t\tContains 1 nuclear receptor DNA-binding domain.
\t\t\t
\t\t\tSWISS:
\t\t\tP06401
\t\t\t
\t\t\tGene ID:
\t\t\t5241
\t\t\t
\t\t\tDatabase links:\t\t\t

Entrez Gene: 5241\xa0Human

Entrez Gene: 5241Entrez Gene: 5241\xa0Human\t\t\t

Entrez Gene: 18667\xa0Mouse

Entrez Gene: 18667Entrez Gene: 18667\xa0Mouse\t\t\t

Entrez Gene: 100009094\xa0Rabbit

Entrez Gene: 100009094Entrez Gene: 100009094\xa0Rabbit\t\t\t

Entrez Gene: 25154\xa0Rat

Entrez Gene: 25154Entrez Gene: 25154\xa0Rat\t\t\t

Omim: 607311\xa0Human

Omim: 607311Omim: 607311\xa0Human\t\t\t

SwissProt: P06401\xa0Human

SwissProt: P06401SwissProt: P06401\xa0Human\t\t\t

SwissProt: Q00175\xa0Mouse

SwissProt: Q00175SwissProt: Q00175\xa0Mouse\t\t\t

SwissProt: P06186\xa0Rabbit

SwissProt: P06186SwissProt: P06186\xa0Rabbit\t\t\t

SwissProt: Q63449\xa0Rat

SwissProt: Q63449SwissProt: Q63449\xa0Rat\t\t\t

Unigene: 2905\xa0Human

Unigene: 2905Unigene: 2905\xa0Human\t\t\t

Unigene: 32405\xa0Human

Unigene: 32405Unigene: 32405\xa0Human\t\t\t

Unigene: 742403\xa0Human

Unigene: 742403Unigene: 742403\xa0Human\t\t\t

Unigene: 12798\xa0Mouse

Unigene: 12798Unigene: 12798\xa0Mouse\t\t\t

Unigene: 437703\xa0Mouse

Unigene: 437703Unigene: 437703\xa0Mouse\t\t\t

Unigene: 1947\xa0Rabbit

Unigene: 1947Unigene: 1947\xa0Rabbit\t\t\t

Unigene: 10303\xa0Rat

Unigene: 10303Unigene: 10303\xa0Rat\t\t\t
\t\t\t
\t\t\tImportant Note:
\t\t\tThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.\t\t\t

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