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CAS No. : 6080-33-7
产品活性：Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-****** receptor.
研究领域：NF-κB | Neuronal Signaling | GPCR/G Protein | Apoptosis | Autophagy
作用靶点：NF-κB | ****** Receptor | Autophagy | Apoptosis
In Vitro: Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne.
In Vivo: I.p. Sinomenine hydrochloride produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test.
相关产品：Apoptosis Compound Library | Natural Product Library Plus | Antioxidants Compound Library | NF-κB Signaling Compound Library | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Natural Product Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Autophagy Compound Library | Immunology/Inflammation Compound Library | LY294002 | Doxorubicin hydrochloride | SP600125 | Y-27632 dihydrochloride | Sorafenib | Trametinib | Bortezomib | Pexidartinib | Tamoxifen | BAY 11-7082 | Decitabine | Acetylcysteine | DAPT | Docetaxel | Temozolomide | 2-Deoxy-D-glucose | Dasatinib | Mdivi-1 | Etoposide | SB 202190 | MPTP hydrochloride | Panobinostat | Rotenone | PD0325901 | Niraparib | Lenalidomide | Cabozantinib | Tanespimycin | Resveratrol | Cytarabine
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。CAS No. : 6080-33-7
CAS No. : CAS No. : 6080-33-76080-33-7产品活性：Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-****** receptor.
产品活性：产品活性：Sinomenine hydrochloride is a blocker of the NF-κBNF-κB activation and also an activator of μ-****** receptorμ-****** receptor.研究领域：NF-κB | Neuronal Signaling | GPCR/G Protein | Apoptosis | Autophagy
研究领域：研究领域：NF-κBNF-κBNF-κB | Neuronal SignalingNeuronal SignalingNeuronal Signaling | GPCR/G ProteinGPCR/G ProteinGPCR/G Protein | ApoptosisApoptosisApoptosis | AutophagyAutophagyAutophagy作用靶点：NF-κB | ****** Receptor | Autophagy | Apoptosis
作用靶点：作用靶点：NF-κBNF-κBNF-κB | ****** Receptor****** Receptor****** Receptor | AutophagyAutophagyAutophagy | ApoptosisApoptosisApoptosisIn Vitro: Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne.
In Vitro: In Vitro: Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne.In Vivo: I.p. Sinomenine hydrochloride produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test.
In Vivo: In Vivo: I.p. Sinomenine hydrochloride produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test.相关产品：Apoptosis Compound Library | Natural Product Library Plus | Antioxidants Compound Library | NF-κB Signaling Compound Library | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Natural Product Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Autophagy Compound Library | Immunology/Inflammation Compound Library | LY294002 | Doxorubicin hydrochloride | SP600125 | Y-27632 dihydrochloride | Sorafenib | Trametinib | Bortezomib | Pexidartinib | Tamoxifen | BAY 11-7082 | Decitabine | Acetylcysteine | DAPT | Docetaxel | Temozolomide | 2-Deoxy-D-glucose | Dasatinib | Mdivi-1 | Etoposide | SB 202190 | MPTP hydrochloride | Panobinostat | Rotenone | PD0325901 | Niraparib | Lenalidomide | Cabozantinib | Tanespimycin | Resveratrol | Cytarabine
相关产品：相关产品：Apoptosis Compound LibraryApoptosis Compound LibraryApoptosis Compound Library | Natural Product Library PlusNatural Product Library PlusNatural Product Library Plus | Antioxidants Compound LibraryAntioxidants Compound LibraryAntioxidants Compound Library | NF-κB Signaling Compound LibraryNF-κB Signaling Compound LibraryNF-κB Signaling Compound Library | GPCR/G Protein Compound LibraryGPCR/G Protein Compound LibraryGPCR/G Protein Compound Library | Neuronal Signaling Compound LibraryNeuronal Signaling Compound LibraryNeuronal Signaling Compound Library | Differentiation Inducing Compound LibraryDifferentiation Inducing Compound LibraryDifferentiation Inducing Compound Library | Oxygen Sensing Compound LibraryOxygen Sensing Compound LibraryOxygen Sensing Compound Library | Natural Product LibraryNatural Product LibraryNatural Product Library | Anti-Cancer Compound LibraryAnti-Cancer Compound LibraryAnti-Cancer Compound Library | Bioactive Compound Library PlusBioactive Compound Library PlusBioactive Compound Library Plus | Autophagy Compound LibraryAutophagy Compound LibraryAutophagy Compound Library | Immunology/Inflammation Compound LibraryImmunology/Inflammation Compound LibraryImmunology/Inflammation Compound Library | LY294002LY294002LY294002 | Doxorubicin hydrochlorideDoxorubicin hydrochlorideDoxorubicin hydrochloride | SP600125SP600125SP600125 | Y-27632 dihydrochlorideY-27632 dihydrochlorideY-27632 dihydrochloride | SorafenibSorafenibSorafenib | TrametinibTrametinibTrametinib | BortezomibBortezomibBortezomib | PexidartinibPexidartinibPexidartinib | TamoxifenTamoxifenTamoxifen | BAY 11-7082BAY 11-7082BAY 11-7082 | DecitabineDecitabineDecitabine | AcetylcysteineAcetylcysteineAcetylcysteine | DAPTDAPTDAPT | DocetaxelDocetaxelDocetaxel | TemozolomideTemozolomideTemozolomide | 2-Deoxy-D-glucose2-Deoxy-D-glucose2-Deoxy-D-glucose | DasatinibDasatinibDasatinib | Mdivi-1Mdivi-1Mdivi-1 | EtoposideEtoposideEtoposide | SB 202190SB 202190SB 202190 | MPTP hydrochlorideMPTP hydrochlorideMPTP hydrochloride | PanobinostatPanobinostatPanobinostat | RotenoneRotenoneRotenone | PD0325901PD0325901PD0325901 | NiraparibNiraparibNiraparib | LenalidomideLenalidomideLenalidomide | CabozantinibCabozantinibCabozantinib | TanespimycinTanespimycinTanespimycin | ResveratrolResveratrolResveratrol | CytarabineCytarabineCytarabine品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
