RRAGA RAS相关GTP结合蛋白A抗体RRAGA RAS相关GTP结合蛋白A抗体RRAGA RAS相关GTP结合蛋白A抗体
| 英文名称 | RRAGA |
| 中文名称 | RAS相关GTP结合蛋白A抗体 |
| 别 名 | FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRAGA:181-280/313 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.
Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
SWISS:
Q7L523
Gene ID:
10670
Database links:Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
| 产品图片 | 
Blank control(blue): Hela cells(fixed with 2% paraformaldehyde (10 min),then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti-RRAGA antibody(bs-5816R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
| 英文名称 | RRAGA |
| 中文名称 | RAS相关GTP结合蛋白A抗体 |
| 别 名 | FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRAGA:181-280/313 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.
Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
SWISS:
Q7L523
Gene ID:
10670
Database links:Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
| 产品图片 |
Blank control(blue): Hela cells(fixed with 2% paraformaldehyde (10 min),then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti-RRAGA antibody(bs-5816R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
| 英文名称 | RRAGA |
英文名称 | 英文名称
RRAGA | RRAGA
| 中文名称 | RAS相关GTP结合蛋白A抗体 |
中文名称 | 中文名称
RAS相关GTP结合蛋白A抗体 | RAS相关GTP结合蛋白A抗体
| 别 名 | FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A. |
别 名 | 别 名
FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A. | FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A.
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
规格价格 | 规格价格
100ul/1380元 购买 200ul/2200元 购买 大包装/询价 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价
| 说 明 书 | 100ul 200ul |
说 明 书 | 说 明 书
100ul 200ul | 100ul 200ul
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 |
研究领域 | 研究领域
肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导
| 抗体来源 | Rabbit |
抗体来源 | 抗体来源
Rabbit | Rabbit
| 克隆类型 | Polyclonal |
克隆类型 | 克隆类型
Polyclonal | Polyclonal
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
交叉反应 | 交叉反应
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
| 产品应用 | IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
产品应用 | 产品应用
IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. | IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
| 分 子 量 | 37kDa |
分 子 量 | 分 子 量
37kDa | 37kDa
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
细胞定位 | 细胞定位
细胞核 细胞浆 细胞膜 | 细胞核 细胞浆 细胞膜
| 性 状 | Lyophilized or Liquid |
性 状 | 性 状
Lyophilized or Liquid | Lyophilized or Liquid
| 浓 度 | 1mg/ml |
浓 度 | 浓 度
1mg/ml | 1mg/ml
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRAGA:181-280/313 |
免 疫 原 | 免 疫 原
KLH conjugated synthetic peptide derived from human RRAGA:181-280/313 | KLH conjugated synthetic peptide derived from human RRAGA:181-280/313
| 亚 型 | IgG |
亚 型 | 亚 型
IgG | IgG
| 纯化方法 | affinity purified by Protein A |
纯化方法 | 纯化方法
affinity purified by Protein A | affinity purified by Protein A
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
储 存 液 | 储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
保存条件 | 保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
| PubMed | PubMed |
PubMed | PubMed
PubMed | PubMed
| 产品介绍 | background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.
Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
SWISS:
Q7L523
Gene ID:
10670
Database links:Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
产品介绍 | 产品介绍
background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.
Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
SWISS:
Q7L523
Gene ID:
10670
Database links:Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
| background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.
Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.
Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
SWISS:
Q7L523
Gene ID:
10670
Database links:
Entrez Gene: 10670 Human
Entrez Gene: 10670 Human
Entrez Gene: 68441 Mouse
Entrez Gene: 68441 Mouse
Entrez Gene: 117044 Rat
Entrez Gene: 117044 Rat
Omim: 612194 Human
Omim: 612194 Human
SwissProt: Q7L523 Human
SwissProt: Q7L523 Human
SwissProt: Q80X95 Mouse
SwissProt: Q80X95 Mouse
SwissProt: Q63486 Rat
SwissProt: Q63486 Rat
Unigene: 702275 Human
Unigene: 702275 Human
Unigene: 31178 Mouse
Unigene: 31178 Mouse
Unigene: 2816 Rat
Unigene: 2816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
| 产品图片 |
Blank control(blue): Hela cells(fixed with 2% paraformaldehyde (10 min),then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti-RRAGA antibody(bs-5816R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
产品图片 | 产品图片
Blank control(blue): Hela cells(fixed with 2% paraformaldehyde (10 min),then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti-RRAGA antibody(bs-5816R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. | Blank control(blue): Hela cells(fixed with 2% paraformaldehyde (10 min),then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti-RRAGA antibody(bs-5816R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
