关键词：IRP-1抗体;铁调节蛋白1抗体;铁调节蛋白1;ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1;ABP55392

关键词：IRP-1抗体;铁调节蛋白1抗体;铁调节蛋白1;ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1;ABP55392

中文名称：铁调节蛋白1多克隆抗体/IRP-1 Polyclonal Antibody

中文名称：铁调节蛋白1多克隆抗体/IRP-1 Polyclonal Antibody铁调节蛋白1多克隆抗体/IRP-1 Polyclonal Antibody铁调节蛋白1多克隆抗体/IRP-1 Polyclonal Antibody

英文名称：IRP-1 Polyclonal Antibody

英文名称：IRP-1 Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP55392.pdf

产品说明书：http://www.abbkine.cn/datasheet/ABP55392.pdf

产品描述：兔抗-铁调节蛋白1 多克隆抗体

产品描述：兔抗-铁调节蛋白1 多克隆抗体

The protein encoded by ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs， which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The protein encoded by ACO1 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

The protein encoded by ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs， which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The protein encoded by ACO1 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

Abbkine致力于为全球生命科学研究和医疗发展提供前沿的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品以及蛋白纯化产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为全球的科学家节省时间并提高研究效率。

AbbkineAbbkine致力于为全球生命科学研究和医疗发展提供前沿的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品以及蛋白纯化产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为全球的科学家节省时间并提高研究效率。