英文名称	phospho-NeuroD1 (Ser274)
中文名称	磷酸化神经细胞分化因子1抗体
别 名	NeuroD1 (phospho S274); p-NeuroD1 (phospho S274); atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NEUROD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; NIDDM.
产品类型	磷酸化抗体
研究领域	肿瘤 心血管 细胞生物 神经生物学 表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Pig, Cow, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	40kDa
细胞定位	细胞核 细胞浆
性 状	Liquid
浓 度	1mg/ml
免 疫 原	KLH conjugated Synthesised acetylpeptide derived from human NeuroD1 around the acetylation site of Ser274:PL(p-S)PP
亚 型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008] Function: Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. DISEASE: Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: Q13562 Gene ID: 4760 Database links: Entrez Gene: 4760 Human Entrez Gene: 18012 Mouse Entrez Gene: 29458 Rat Omim: 601724 Human SwissProt: Q13562 Human SwissProt: Q60867 Mouse SwissProt: Q64289 Rat Unigene: 574626 Human Unigene: 709709 Human Unigene: 4636 Mouse Unigene: 44289 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

英文名称phospho-NeuroD1 (Ser274)中文名称磷酸化神经细胞分化因子1抗体别 名NeuroD1 (phospho S274); p-NeuroD1 (phospho S274); atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NEUROD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; NIDDM.产品类型磷酸化抗体研究领域肿瘤 心血管 细胞生物 神经生物学 表观遗传学抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, (predicted: Pig, Cow, Sheep, )产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量40kDa细胞定位细胞核 细胞浆性 状Liquid浓 度1mg/ml免 疫 原KLH conjugated Synthesised acetylpeptide derived from human NeuroD1 around the acetylation site of Ser274:PL(p-S)PP亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Function:
Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.

DISEASE:
Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
Q13562

Gene ID:
4760

Database links:

Entrez Gene: 4760 Human

Entrez Gene: 18012 Mouse

Entrez Gene: 29458 Rat

Omim: 601724 Human

SwissProt: Q13562 Human

SwissProt: Q60867 Mouse

SwissProt: Q64289 Rat

Unigene: 574626 Human

Unigene: 709709 Human

Unigene: 4636 Mouse

Unigene: 44289 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.英文名称phospho-NeuroD1 (Ser274)英文名称英文名称phospho-NeuroD1 (Ser274)phospho-NeuroD1 (Ser274)中文名称磷酸化神经细胞分化因子1抗体中文名称中文名称磷酸化神经细胞分化因子1抗体磷酸化神经细胞分化因子1抗体别 名NeuroD1 (phospho S274); p-NeuroD1 (phospho S274); atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NEUROD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; NIDDM.别 名别 名NeuroD1 (phospho S274); p-NeuroD1 (phospho S274); atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NEUROD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; NIDDM.NeuroD1 (phospho S274); p-NeuroD1 (phospho S274); atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NEUROD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; NIDDM.产品类型磷酸化抗体产品类型产品类型磷酸化抗体磷酸化抗体研究领域肿瘤 心血管 细胞生物 神经生物学 表观遗传学研究领域研究领域肿瘤 心血管 细胞生物 神经生物学 表观遗传学肿瘤 心血管 细胞生物 神经生物学 表观遗传学抗体来源Rabbit抗体来源抗体来源RabbitRabbit克隆类型Polyclonal克隆类型克隆类型PolyclonalPolyclonal交叉反应Human, Mouse, Rat, (predicted: Pig, Cow, Sheep, )交叉反应交叉反应Human, Mouse, Rat, (predicted: Pig, Cow, Sheep, )Human, Mouse, Rat, (predicted: Pig, Cow, Sheep, )产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.产品应用产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量40kDa分 子 量分 子 量40kDa40kDa细胞定位细胞核 细胞浆细胞定位细胞定位细胞核 细胞浆细胞核 细胞浆性 状Liquid性 状性 状LiquidLiquid浓 度1mg/ml浓 度浓 度1mg/ml1mg/ml免 疫 原KLH conjugated Synthesised acetylpeptide derived from human NeuroD1 around the acetylation site of Ser274:PL(p-S)PP免 疫 原免 疫 原KLH conjugated Synthesised acetylpeptide derived from human NeuroD1 around the acetylation site of Ser274:PL(p-S)PPKLH conjugated Synthesised acetylpeptide derived from human NeuroD1 around the acetylation site of Ser274:PL(p-S)PP亚 型IgG亚 型亚 型IgGIgG纯化方法affinity purified by Protein A纯化方法纯化方法affinity purified by Protein Aaffinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.储 存 液储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.保存条件保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMedPubMedPubMedPubMedPubMedPubMed产品介绍This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Function:
Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.

DISEASE:
Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
Q13562

Gene ID:
4760

Database links:

Entrez Gene: 4760 Human

Entrez Gene: 18012 Mouse

Entrez Gene: 29458 Rat

Omim: 601724 Human

SwissProt: Q13562 Human

SwissProt: Q60867 Mouse

SwissProt: Q64289 Rat

Unigene: 574626 Human

Unigene: 709709 Human

Unigene: 4636 Mouse

Unigene: 44289 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.产品介绍产品介绍This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Function:
Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.

DISEASE:
Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
Q13562

Gene ID:
4760

Database links:

Entrez Gene: 4760 Human

Entrez Gene: 18012 Mouse

Entrez Gene: 29458 Rat

Omim: 601724 Human

SwissProt: Q13562 Human

SwissProt: Q60867 Mouse

SwissProt: Q64289 Rat

Unigene: 574626 Human

Unigene: 709709 Human

Unigene: 4636 Mouse

Unigene: 44289 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Function:
Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.

DISEASE:
Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
Q13562

Gene ID:
4760

Database links:

Entrez Gene: 4760 Human

Entrez Gene: 4760Entrez Gene: 4760 Human

Entrez Gene: 18012 Mouse

Entrez Gene: 18012Entrez Gene: 18012 Mouse

Entrez Gene: 29458 Rat

Entrez Gene: 29458Entrez Gene: 29458 Rat

Omim: 601724 Human

Omim: 601724Omim: 601724 Human

SwissProt: Q13562 Human

SwissProt: Q13562SwissProt: Q13562 Human

SwissProt: Q60867 Mouse

SwissProt: Q60867SwissProt: Q60867 Mouse

SwissProt: Q64289 Rat

SwissProt: Q64289SwissProt: Q64289 Rat

Unigene: 574626 Human

Unigene: 574626Unigene: 574626 Human

Unigene: 709709 Human

Unigene: 709709Unigene: 709709 Human

Unigene: 4636 Mouse

Unigene: 4636Unigene: 4636 Mouse

Unigene: 44289 Rat

Unigene: 44289Unigene: 44289 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.