英文名称	TRPV6
中文名称	钙转运蛋白1抗体
别 名	ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB.

英文名称TRPV6中文名称钙转运蛋白1抗体别 名ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB.英文名称TRPV6英文名称英文名称TRPV6TRPV6中文名称钙转运蛋白1抗体中文名称中文名称钙转运蛋白1抗体钙转运蛋白1抗体别 名ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB.别 名别 名ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB.ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB.

研究领域	信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	83kDa
细胞定位	细胞膜
性 状	Liquid
浓 度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human TRPV6:4-100/725
亚 型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011]. Function: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). Subunit: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin. Subcellular Location: Cell membrane; Multi-pass membrane protein (By similarity). Tissue Specificity: Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. Post-translational modifications: Glycosylated (By similarity). Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation. Similarity: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. Contains 6 ANK repeats. SWISS: Q9H1D0 Gene ID: 55503 Database links: Entrez Gene: 55503 Human Entrez Gene: 64177 Mouse Entrez Gene: 114246 Rat Omim: 606680 Human SwissProt: Q9H1D0 Human SwissProt: Q91WD2 Mouse SwissProt: Q9R186 Rat Unigene: 302740 Human Unigene: 638966 Human Unigene: 296889 Mouse Unigene: 205943 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

研究领域信号转导抗体来源Rabbit克隆类型Polyclonal交叉反应Mouse, (predicted: Human, Rat, )产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量83kDa细胞定位细胞膜性 状Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human TRPV6:4-100/725亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011].

Function:
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Subunit:
Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Post-translational modifications:
Glycosylated (By similarity).
Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
Contains 6 ANK repeats.

SWISS:
Q9H1D0

Gene ID:
55503

Database links:

Entrez Gene: 55503 Human

Entrez Gene: 64177 Mouse

Entrez Gene: 114246 Rat

Omim: 606680 Human

SwissProt: Q9H1D0 Human

SwissProt: Q91WD2 Mouse

SwissProt: Q9R186 Rat

Unigene: 302740 Human

Unigene: 638966 Human

Unigene: 296889 Mouse

Unigene: 205943 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications研究领域信号转导研究领域研究领域信号转导信号转导抗体来源Rabbit抗体来源抗体来源RabbitRabbit克隆类型Polyclonal克隆类型克隆类型PolyclonalPolyclonal交叉反应Mouse, (predicted: Human, Rat, )交叉反应交叉反应Mouse, (predicted: Human, Rat, )Mouse, (predicted: Human, Rat, )产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.产品应用产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量83kDa分 子 量分 子 量83kDa83kDa细胞定位细胞膜细胞定位细胞定位细胞膜细胞膜性 状Liquid性 状性 状LiquidLiquid浓 度1mg/ml浓 度浓 度1mg/ml1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human TRPV6:4-100/725免 疫 原免 疫 原KLH conjugated synthetic peptide derived from human TRPV6:4-100/725KLH conjugated synthetic peptide derived from human TRPV6:4-100/725亚 型IgG亚 型亚 型IgGIgG纯化方法affinity purified by Protein A纯化方法纯化方法affinity purified by Protein Aaffinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.储 存 液储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.保存条件保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMedPubMedPubMedPubMedPubMedPubMed产品介绍This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011].

Function:
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Subunit:
Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Post-translational modifications:
Glycosylated (By similarity).
Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
Contains 6 ANK repeats.

SWISS:
Q9H1D0

Gene ID:
55503

Database links:

Entrez Gene: 55503 Human

Entrez Gene: 64177 Mouse

Entrez Gene: 114246 Rat

Omim: 606680 Human

SwissProt: Q9H1D0 Human

SwissProt: Q91WD2 Mouse

SwissProt: Q9R186 Rat

Unigene: 302740 Human

Unigene: 638966 Human

Unigene: 296889 Mouse

Unigene: 205943 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications产品介绍产品介绍This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011].

Function:
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Subunit:
Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Post-translational modifications:
Glycosylated (By similarity).
Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
Contains 6 ANK repeats.

SWISS:
Q9H1D0

Gene ID:
55503

Database links:

Entrez Gene: 55503 Human

Entrez Gene: 64177 Mouse

Entrez Gene: 114246 Rat

Omim: 606680 Human

SwissProt: Q9H1D0 Human

SwissProt: Q91WD2 Mouse

SwissProt: Q9R186 Rat

Unigene: 302740 Human

Unigene: 638966 Human

Unigene: 296889 Mouse

Unigene: 205943 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applicationsThis gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011].

Function:
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Subunit:
Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Post-translational modifications:
Glycosylated (By similarity).
Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
Contains 6 ANK repeats.

SWISS:
Q9H1D0

Gene ID:
55503

Database links:

Entrez Gene: 55503 Human

Entrez Gene: 55503Entrez Gene: 55503 Human

Entrez Gene: 64177 Mouse

Entrez Gene: 64177Entrez Gene: 64177 Mouse

Entrez Gene: 114246 Rat

Entrez Gene: 114246Entrez Gene: 114246 Rat

Omim: 606680 Human

Omim: 606680Omim: 606680 Human

SwissProt: Q9H1D0 Human

SwissProt: Q9H1D0SwissProt: Q9H1D0 Human

SwissProt: Q91WD2 Mouse

SwissProt: Q91WD2SwissProt: Q91WD2 Mouse

SwissProt: Q9R186 Rat

SwissProt: Q9R186SwissProt: Q9R186 Rat

Unigene: 302740 Human

Unigene: 302740Unigene: 302740 Human

Unigene: 638966 Human

Unigene: 638966Unigene: 638966 Human

Unigene: 296889 Mouse

Unigene: 296889Unigene: 296889 Mouse

Unigene: 205943 Rat

Unigene: 205943Unigene: 205943 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications