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【Molecular Wt.】Predicted：118 kDa ,observed：114-173 kDa.
【Molecular Wt.】Predicted：118 kDa ,observed：114-173 kDa.【Description】It has long been known that the overexpression of either Wnt-1 or the GLI proteins results in cancer; however, the molecular basis for this transformation was poorly understood. The Wnt-1 and GLI proteins have now been placed in a signaling cascade downstream of the mammalian homologs of the Drosophila hedgehog and patched proteins. The Drosophila segment polarity gene hedgehog (hh) encodes a secreted protein that appears to function in embryonic and imaginal disc patterning. The ptc gene, also identified as a Drosophila segment polarity gene, encodes the transmembrane protein patched, the expression of which is precisely regulated during embryonic development. Hedgehog has been shown to enhance the expression of the Wnt family of proteins through a signaling cascade involving the GLI transcription factors, while patched functions as a repressor opposing the effects of hedgehog. Mutations in the ptc gene, which result in unregulated hedgehog signaling, have been correlated with the most common type of cancer, basal cell carcinoma, which affects 750,000 individuals annually in the United States alone.
【Description】It has long been known that the overexpression of either Wnt-1 or the GLI proteins results in cancer; however, the molecular basis for this transformation was poorly understood. The Wnt-1 and GLI proteins have now been placed in a signaling cascade downstream of the mammalian homologs of the Drosophila hedgehog and patched proteins. The Drosophila segment polarity gene hedgehog (hh) encodes a secreted protein that appears to function in embryonic and imaginal disc patterning. The ptc gene, also identified as a Drosophila segment polarity gene, encodes the transmembrane protein patched, the expression of which is precisely regulated during embryonic development. Hedgehog has been shown to enhance the expression of the Wnt family of proteins through a signaling cascade involving the GLI transcription factors, while patched functions as a repressor opposing the effects of hedgehog. Mutations in the ptc gene, which result in unregulated hedgehog signaling, have been correlated with the most common type of cancer, basal cell carcinoma, which affects 750,000 individuals annually in the United States alone.【Species Reactivity】Human;Mouse;Rat
【Species Reactivity】Human;Mouse;Rat【Tested applications】WB;IP;IF;IHC-P
【Tested applications】WB;IP;IF;IHC-P【Antibody type】Rabbit polyclonal Antibody
【Antibody type】Rabbit polyclonal Antibody【Immunogen】Amino acids 781-1080 of GLI-1 of human origin.
【Immunogen】Amino acids 781-1080 of GLI-1 of human origin.【Positive control】
【Positive control】【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】Gli 1 antibody
GLI antibody
GLI family zinc finger 1 antibody
GLI Kruppel family member 1 antibody
gli1 antibody
GLI1_HUMAN antibody
Glioma associated oncogene 1 antibody
Glioma associated oncogene homolog 1 (zinc finger protein) antibody
Glioma associated oncogene homolog antibody
Glioma-associated oncogene antibody
Oncogene GLI antibody
Zfp 5 antibody
Zfp5 antibody
Zinc finger protein GLI 1 antibody
Zinc finger protein GLI1 antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃
【Stroage】Store at +4℃【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG
【Isotype】IgG【Purity】Immunogen affinity purified
【Purity】Immunogen affinity purified【Subcellular location】Cytoplasm, Nucleus
【Subcellular location】Cytoplasm, Nucleus【Background References】1. Leovic, D. et al. 2012. Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head Neck. 34: 104-112.
2. Liu, Z. et al. 2012. Blockade of Autocrine TGF-β Signaling Inhibits Stem Cell Phenotype, Survival, and Metastasis of Murine Breast Cancer Cells. Journal of stem cell research & therapy. 2: 1-8.
3. Ren YR et al. 2011. Structural Analysis of the Cancer-specific Promoter in Mesothelin and in Other Genes Overexpressed in Cancers. J Biol Chem. . 286: 11960-11969.
【DatasheetURL】http://www.huabio.com/upload/RT1242.pdf
【DatasheetURL】http://www.huabio.com/upload/RT1242.pdf【Uniprot ID】P08151
【Uniprot ID】P08151【Raised in】Rabbit
【Raised in】Rabbit【Clone No.】
【Clone No.】
