【Molecular Wt.】87 kDa
【Molecular Wt.】87 kDa【Description】AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common “PAS” motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 2 (aryl hydrocarbon receptor nuclear translocator 2), also known as Hif-2b or bHLHe1, is a 712 amino acid nuclear protein that is exclusively expressed in adult brain and kidney. Containing a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains, Arnt 2 specifically recognizes the xenobiotic response element (XRE).
【Description】AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common “PAS” motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 2 (aryl hydrocarbon receptor nuclear translocator 2), also known as Hif-2b or bHLHe1, is a 712 amino acid nuclear protein that is exclusively expressed in adult brain and kidney. Containing a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains, Arnt 2 specifically recognizes the xenobiotic response element (XRE).【Species Reactivity】Human
【Species Reactivity】Human【Tested applications】WB;IHC
【Tested applications】WB;IHC【Antibody type】Recombinant Rabbit monoclonal Antibody
【Antibody type】Recombinant Rabbit monoclonal Antibody【Immunogen】recombinant protein
【Immunogen】recombinant protein【Positive control】Human liver tissue.
【Positive control】Human liver tissue.【Conjugate】Non-conjugated
【Conjugate】Non-conjugated【Alternative names】arnT antibody
ARNT protein antibody
ARNT_HUMAN antibody
Aryl hydrocarbon receptor nuclear translocator antibody
bHLHe2 antibody
Class E basic helix-loop-helix protein 2 antibody
Dioxin receptor antibody
Dioxin receptor nuclear translocator antibody
Drnt antibody
HIF 1 beta antibody
HIF 1beta antibody
HIF-1-beta antibody
HIF1-beta antibody
HIF1B antibody
HIF1beta antibody
Hypoxia Inducible Factor 1 antibody
Hypoxia inducible factor 1 beta antibody
Hypoxia-inducible factor 1-beta antibody
nuclear translocator antibody
Tango antibody
【Form】Liquid
【Form】Liquid【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.【Isotype】IgG
【Isotype】IgG【Purity】Protein A purified.
【Purity】Protein A purified.【Subcellular location】Nucleus.
【Subcellular location】Nucleus.【Background References】1. Bian Y., et al. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics 96:253-262(2014).
2. Van Damme P., et al. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
【DatasheetURL】http://www.huabio.com/upload/ET1609-67.pdf
【DatasheetURL】http://www.huabio.com/upload/ET1609-67.pdf【Uniprot ID】P27540(Human)
【Uniprot ID】P27540(Human)【Raised in】Rabbit
【Raised in】Rabbit【Clone No.】ST05-25
【Clone No.】ST05-25
