本公司提供科研PAPP A2妊娠相关血浆蛋白A2抗体PAPP A2妊娠相关血浆蛋白A2抗体，抗体质量可靠，订购PAPP A2妊娠相关血浆蛋白A2抗体PAPP A2妊娠相关血浆蛋白A2抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：妊娠相关血浆蛋白A2抗体妊娠相关血浆蛋白A2抗体
英文名称：Anti-PAPP A2Anti-PAPP A2
货号：bs-9916R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 199kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.Subcellular Location : Secreted.Tissue Specificity : Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.