内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by reduced SDS-PAGE.

活性:


产品背景:
Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

产品描述:
Human Coagulation Factor II, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 69.5 kDa. The predicted N-terminus is Gln 25. The reducing (R) protein migrates as 85-110 kDa in SDS-PAGE due to glycosylation.