β-Nerve growth factor (β-NGF) is a neurotrophin that is involved in the regulation of growth, proliferation, and survival of sympathetic and sensory neurons.{53786} Ngf encodes pro-NGF, a 27 kDa protein that is composed of an N-terminal signal peptide and α-, γ-, and β-NGF domains. β-NGF, also known as mature or functional NGF, is produced after degradation of the signaling peptide and proteolytic cleavage.{53789,52615} β-NGF homodimerizes and induces neurotropic signaling through tropomyosin-related kinase A (TrkA) and the p75 neurotrophin receptor (p75NTR).{53787} β-NGF is produced by neurons in the cortex, pituitary gland, hippocampus, basal ganglia, thalamus, spinal cord, and retina, as well as in non-neuronal target cells of sympathetic and sensory neurons such as keratinocytes, vascular smooth muscle cells, exocrine salivary glands, and endocrine tissues.{53787,53788} Exogenous administration of β-NGF improves neurological deficits in murine models of traumatic brain injury (TBI).{53787} Exogenous administration of β-NGF also accelerates the rate of skin excision wound healing in rats. Cayman’s β-NGF (mouse, recombinant) protein can be used for cell-based assay applications. This protein consists of 121 amino acids and has a calculated molecular weight of 13.5 kDa.