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| Description |  | Monoclonal Antibody against High Molecular Weight MAP2 |
| Intended Use | | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Clone | | AA5 |
| Form | | MAP 2 Monoclonal Antibody Ascites |
| Host | | Mouse |
| Species Reactivity | | All mammalian species |
| IsoType | | IgG2a |
| [Ab] | | 1 mg/mL |
| Specificity | | MAP 2 Monoclonal Antibody Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription. This antibody only recognizes the high molecular weight forms MAP2A and MAP2B. It will stain neuronal cell bodies and dendritic processes, and will not stain glial cells or axons. It is the best marker to distinguish dendrites from axons in the brain. |
| Uses | | This antibody is effective in Western blot. |
| Suggested Working Dilution | | The optimal working dilution should be determined for each specific assay condition.
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| Notes | | *Predicted MW=280kDa |
| Storage | | Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. |
| Warranty/Conditions | | Covance products may not be resold or modified for resale without prior written approval. |
