关键词：Amyloid-β抗体;β-淀粉样蛋白抗体;β-淀粉样蛋白;APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II;ABP50653

中文名称：β-淀粉样蛋白多克隆抗体/Amyloid-β Polyclonal Antibody

英文名称：Amyloid-β Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP50653.pdf

产品描述：兔抗-β-淀粉样蛋白 多克隆抗体

APP encodes a cell surface receptor and transmembrane precursor protein (amyloid beta precursor protein) that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for APP.

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