| Background: | Thisgeneencodesabifunctionalproteinthatcatalyzesthelasttwostepso fthedenovopurinebiosyntheticpathway.TheN-terminaldomainhasphosphoribosylaminoimidazolecarboxamidefor myltransferaseactivity,andtheC-terminaldomainhasIMPcyclohydrolaseactivity.Amutationinthisgener esultsinAICA-ribosiduria.[providedbyRefSeq]. |
| Applications: | WB,FC |
| Nameofantibody: | ATIC |
| Immunogen: | FusionproteinofhumanATIC |
| Fullname: | 5-aminoimidazole-4-carboxamideribonucleotideformyltransferase/IMPcyclohydrolase(ATIC) |
| Synonyms: | AICAR;AICARFT;HEL-S-70p;IMPCHASE;PURH |
| SwissProt: | P31939 |
| WBPredictedbandsize: | 65kDa |
| WBPositivecontrol: | HepG2,Hela,SVT2,A549,COS7,MDCK,PC12,MCF-7celllysates |
| WBRecommendeddilution: | 500-2000 |
