本公司提供科研FGF10成纤维细胞生长因子10抗体，抗体质量可靠，订购FGF10成纤维细胞生长因子10抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：成纤维细胞生长因子10抗体
英文名称：Anti-FGF10
货号：bs-1326R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, cow, shp, dog, chk, Gpig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：FGF10/FGF-10 (fibroblast growth factor 10) is a heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. FGF10 binds the KGFR receptor, a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis. FGF10 is mostly related to FGF-7/KGF and is expressed during development and preferentially in adult lungs.Function : Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.Subcellular Location : Secreted.DISEASE : Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.Similarity : Belongs to the heparin-binding growth factors family.FGF-10对于角质形成细胞的异常增殖和分化异常可能有着重要的调节作用。有学者认为；有关部分肿瘤、胚胎发育紊乱、生长发育障碍性疾病、炎症及修复异常、免疫性疾病，血液病，HIV感染等都与FGF-10有关。