产品货号:jlcR18103
英文名称:HUCE1
中文名称:脑蛋白1抗体
别名:Cerebral protein 1; hypothetical protein LOC23378; KIAA0409; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA processing protein 8; Ribosomal RNA-processing protein 8; RRP 8; RRP8; RRP8 methyltransferase homolog; RRP8_HUMAN.
研究领域 :细胞生物神经生物学信号转导
抗体来源:Rabbit
克隆类型:Polyclonal
交叉反应: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量:51kDa
细胞定位:细胞核
性状 :Lyophilized or Liquid
浓度:1mg/ml
免疫原:KLH conjugated synthetic peptide derived from human HUCE1:131-230/456
亚型:IgG
纯化方法 :affinity purified by Protein A
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :PubMed
产品介绍: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Subcellular Location:
Nucleus > nucleolus. Localizes at rDNA locus.
Similarity:
Belongs to the methyltransferase superfamily. RRP8 family.
SWISS:
O43159
Gene ID:
23378
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
