本公司提供科研MMP-11基质金属蛋白酶-11抗体，抗体质量可靠，订购MMP-11基质金属蛋白酶-11抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：基质金属蛋白酶-11抗体
英文名称：Anti-MMP-11
货号：bs-1853R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 43/51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1 proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.Subcellular Location : Secreted, extracellular space, extracellular matrix (Probable).Tissue Specificity : Specifically expressed in stromal cells of breast carcinomas.Similarity : Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains.