Catalog #: DC398 Derived From: Human Cells
Description:
Recombinant Human Cathepsin B/CTSB (C-6His) is produced by Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus.
Accession: P07858
Names(Known as):Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB
Quality Control:
Mol Mass: 36.9kDa AP Mol Mass: 40kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
