中文名称:血管紧张素转换酶2单克隆抗体
英文名称:ACE2
别 名:ACE-2; ACE 2; Angiotensin converting enzyme 2; ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014; EC 3.4.17; angiotensin-converting enzyme 2 precursor; ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2.
货号:YLK-KT0546
分 子 量:87kDa
细胞定位:细胞膜 分泌型蛋白
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

产品介绍:血管紧张素转换酶 2 (ACE2) 是一种外肽酶,可催化血管紧张素 I 转化为九肽血管紧张素 [1-9],或催化血管紧张素 II 转化为血管紧张素 1-7。 ACE2对心脏功能有直接影响,主要在心脏和肾脏的血管内皮细胞中表达。 ACE2 对用于治疗高血压的 ACE 抑制剂药物不敏感。
ACE2 受体已被证明是某些冠状病毒(包括 SARS 病毒)进入人体细胞的入口点[10]。 许多研究已经确定,SARS-CoV-2(即 COVID-19 病毒)的切入点是相同的。
Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and *********-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Subunit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.
Subcellular Location:
Processed angiotensin-converting enzyme 2: Secreted.
Cell membrane; Single-pass type I membrane protein.
注意:
所提供的本产品仅供研究使用,不得用于人类、治疗或诊断应用。

