产品货号:jlcR19858
英文名称:RGS18
中文名称:G蛋白信号转导调节因子18抗体
别名:Regulator of G protein signalling 13; Regulator of G Protein Signalling 18; Regulator of G-protein signaling 18; RGS 18; RGS13; RGS18; RGS18_HUMAN.
研究领域:细胞生物信号转导 G蛋白信号
抗体来源:Rabbit
克隆类型:Polyclonal
交叉反应: Human, Mouse, Rat, Dog, Pig, Cow,
产品应用:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量:28kDa
细胞定位:细胞浆
性状:Lyophilized or Liquid
浓度:1mg/ml
免疫原:KLH conjugated synthetic peptide derived from human RGS18:1-100/255
亚型:IgG
纯化方法:affinity purified by Protein A
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :PubMed
产品介绍:This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.
Similarity:
Contains 1 RGS domain.
SWISS:
Q9NS28
Gene ID:
64407
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
