SPIN1抗体| SPIN1 antibody

货号 PAab08177

蛋白别名 OCR antibody, SPIN

蛋白介绍

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

产品描述

anti-SPIN1 antibody is a Rabbit Polyclonal antibody againstSPIN1..

建议稀释比例

IHC

Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using PAab08177( SPIN1 Antibody) at dilution of 1:50

Western blot

HeLa cells were subjected to SDS PAGE followed by western blot with PAab08177(SPIN1 antibody) at dilution of 1:800(本抗体仅供体外科研用途，不可用于临床诊断!)

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