Anti-DDB2 antibody

Cat. No. JC220538
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description Anti-DDB2 rabbit polyclonal antibody
Applications ELISA, IHC 
Immunogen Fusion protein of human DDB2
Reactivity Human, Mouse
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification

Target information
Symbol DDB2
Full name damage-specific DNA binding protein 2
Synonyms XPE; DDBB; UV-DDB2
Swissprot Q92466

Target Background
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Anti-DDB2 antibody
Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 25-100 Predicted cell location: Nucleus
Positive control: Human colorectal cancer
Recommended dilution: 25-100