AS 8351组蛋白去甲基化酶抑制剂

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Biogems
2021-06-10 09:54

上海研卉生物科技有限公司

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上海研卉生物科技有限公司
李先生
18702156455 021-69000211
yanhuibio@163.com
产品属性
规格10mg
产品说明
AS 8351组蛋白去甲基化酶抑制剂
Catalog Number : 7964296

Description

AS 8351 is an iron chelator and histone demethylase inhibitor, targeting KDM5B (JARID1B). It is reported to efficiently induce cardiac reprogramming of human fibroblasts in conjunction with other small molecules. KDM5B is a multi-domain demethylase enzyme that is overexpressed in many cancer types.
product image

Additional Information

Applications
FA
Synonyms:
AS8351, AS-8351, NSC-51355, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone
Formulation:
Crystalline solid
Chemical Name:
N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
Molecular Formula:

C17H13N3O2

Molecular Weight:
291.3
CAS Number
796-42-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Cao, N., Huang, Y., Zheng, J., Spencer, C. I., Zhang, Y., Fu, J. D., ... & Ma, T. (2016). Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science352(6290), 1216-1220.

Chen, Y., Yang, Z., Zhao, Z. A., & Shen, Z. (2017). Direct reprogramming of fibroblasts into cardiomyocytes. Stem cell research & therapy8(1), 118.

Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., ... & Ponder, B. A. (2010). Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular cancer9(1), 59.