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英文名称 :Anti-TLR9/CD289

中文名称 :Toll样受体9抗体

英文别 名 :Toll-like receptor 9; CD 289; CD289; TLR 9; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; TLR9_HUMAN.

浓 度 : 1mg/1ml

规 格 :0.1ml/100μg 0.2ml/200μg

使用范围：仅限科研使用,不能应用于临床

应用：IH(P)免疫组化(石蜡)；IC细胞免疫化学；WB免疫印迹；FC流式细胞检测；ELISA

保存条件：连续使用时4°C存储,保质期六个月；长期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。

抗体来源 :Rabbit

克隆类型 :polyclonal

交叉反应 :Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

产品类型 :一抗

研究领域: 免疫学 神经生物学 信号转导 细胞周期蛋白

蛋白分子量: predicted molecular weight: 113kDa

性 状 :Lyophilized or Liquid

免 疫 原 :KLH conjugated synthetic peptide derived from human TLR9

亚 型 :IgG

纯化方法 :affinity purified by Protein A

储 存 液 :0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

保存条件 :
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 :
TLR9 is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The gene encoding this protein is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
Function : Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Subunit : Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with CNPY3 (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with BTK.
Subcellular Location : Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity).
Tissue Specificity : Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c immature dendritic cells. Also detected in lung and liver.
Similarity : Belongs to the Toll-like receptor family. Contains 26 LRR (leucine-rich) repeats. Contains 1 TIR domain.
Database links : UniProtKB/Swiss-Prot: Q9NR96.2