人高灵敏白细胞介素8(IL-8)ELISA试剂盒 

货号:LM-81000HK

规格:48T/96T

种属:Human

范围:0.78-50pg/ml

灵敏度:0.46pg/ml

用途: For quantitative detection of IL-8 in serum, plasma, tissue homogenates and other biologicalfluids.

存储:2-8°C 

截止日期: see kit label

原理:Sandwich

注意:仅供研究使用。

Background

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlikemany other cytokines, it has distinct target specificity for the neutrophil, with only weak effects on otherblood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regions. The importance ofneutrophil functions has been recognized in periodontal disease for many years. Neutrophils represent themajor population of immigrant cells in periodontitis. In diseases with neutrophil dysfunctions periodontaltissue is lost very rapidly. The response of neutrophils to IL-8 is characterized by migration of the cells, therelease of granule enzymes, and other intra- and extracellular changes. Connective tissue constituents areefficiently degraded by neutrophil enzymes, released upon activation. Interleukin-8 is a member of theInterleukin-8 supergene family that includes other small chemotactic peptides with structural homology. Italso shares with other cytokines DNA sequence features that suggest common regulatory pathways. In vivointracutaneous application of IL-8 induces local exudation and a massive, long-lasting accumulation ofneutrophils. Though IL-8 plays a role in the cytokine network, its major pathophysiological role lies inaffecting neutrophils.

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！