关于Adiponectin/Acrp30: Adiponectin is a secreted protein.It is synthesized exclusively by adipocytes and secreted into plasma.Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity,with direct anti-diabetic,anti-atherogenic and anti-inflammatory activities.Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle,enhancing glucose utilization and fatty-acid combustion.Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages,and also by counteracting its effects.It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.Adiponectin may play a role in cell growth,angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities,depending on the type of complex:LMW,MMW or HMW.