产品货号:jlcR2939 中文名称:Ras相关结构域蛋白质2抗体 别名:CENP 34; Centromere protein 34; Ras association (RalGDS/AF 6) domain family 2; Ras association (RalGDS/AF-6) domain family member 2; Ras association domain containing protein 2; Ras association domain-containing protein 2; RASF2_HUMAN; RASFADIN; RASSF2; RP4-599I11.1. 研究领域:肿瘤免疫学染色质和核信号信号转导 G蛋白偶联受体 表观遗传学 G蛋白信号 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应: Human, Mouse, Rat, Dog, Pig, Horse, 产品应用:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量:38kDa 细胞定位:细胞核 性状:Lyophilized or Liquid 浓度:1mg/ml 免疫原:KLH conjugated synthetic peptide derived from human RASSF2:201-300/326 亚型:IgG 纯化方法:affinity purified by Protein A 储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍background: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.
Function: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
Subunit: Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
Subcellular Location: Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
Tissue Specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
Post-translational modifications: Phosphorylated by STK3/MST2 and STK4/MST1.
Similarity: Contains 1 Ras-associating domain. Contains 1 SARAH domain.
SWISS: P50749
Gene ID: 9770
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
