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| 货号 | Z10788 |
| 规格 | 50μl | 100μl | 150μl |
| 抗体名称 | Anti-Androgen receptor/AR Antibody |
| 指标别名 | AIS;androgen receptor;AR;DHTR;Dihydrotestosterone receptor;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM,ELISA |
| 基因名称 | AR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Androgen Receptor/AR recombinant protein (Position:A629-Q920). |
| 实际分子量 | 110～120KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The AR (androgen receptor) gene is more than 90kb long and codes for a protein that has 3 major functional domains:the N-terminal domain,DNA-binding domain,and androgen-binding domain.The AR gene is mapped to Xq12.The protein functions as a steroid-hormone activated transcription factor.Upon binding the hormone ligand,the receptor dissociates from accessory proteins,translocates into the nucleus,dimerizes,and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein.Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease).Mutations in this gene are also associated with complete androgen insensitivity (CAIS).Two alternatively spliced variants encoding distinct isoforms have been described. |
| Uniprot ID | P10275 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | androgen receptor |
| 蛋白名全称 | Androgen receptor |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 |
