| 抗体名称 | Anti-SP110 Antibody |
| 指标别名 | IFI41;IFI75;IPR1;SP110;SP110 nuclear body protein;Speckled 110kDa;VODI |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | SP110 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | IPR1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1.The immunogen is located within amino acids 470 - 520 of IPR1. |
| 计算分子量 | 78kDa |
| 成分 | IPR1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | IPR1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene.IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component.The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator.Alternative splicing has been observed for this gene and three transcript variants,encoding distinct isoforms,have been identified.SP110 is the closest homolog of the IPR1 protein in humans.The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity,cell death,and pathogenesis.IPR1/Sp110 is up-regulated after infection with M.tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis. |
| Uniprot ID | Q9HB58 |
| 基因名全称 | SP110 nuclear body protein |
| 蛋白名全称 | SP110 nuclear body protein |
| 推荐稀释比 | Ipr1 antibody can be used for detection of Ipr1 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
