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| 货号 | Z37734 |
| 规格 | 50μl | 100μl | 150μl |
| 抗体名称 | Anti-FAP Antibody |
| 指标别名 | FAP;Prolyl endopeptidase FAP;Dipeptidyl peptidase FAP;SIMP |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | FAP |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human FAP1 |
| 实际分子量 | 95KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | FAP(Fibroblast Activation Protein,Alpha) also known as FAPA or SEPRASE,is an inducible cell surface glycoprotein that was originally identified in cultured fibroblasts using monoclonal antibody F19.The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family.The FAP gene is mapped on 2q24.2.FAP is most closely related to DPPIV and they share about 50% of their amino acids.FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity.Its gelatinase activity requires a glycine in P2 position.FAP-alpha shows 48% amino acid identity with dipeptidyl peptidase IV and 30% identity with DPP4-related protein.Northern blot analysis detected a 2.8-kb FAP-alpha mRNA in fibroblasts.Depletion of FAP-expressing cells,which made up only 2% of all tumor cells in established Lewis lung carcinomas,caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-gamma and tumor necrosis factor-alpha. |
| Uniprot ID | Q12884 |
| 基因名全称 | Prolyl endopeptidase FAP |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 |
