产品编号: KMP2243 产品名称: Human TNFRSF17 Protein, His Tag, Flag Tag 中文名称: 重组人TNFRSF17蛋白 中文全称: 重组人B细胞成熟抗原蛋白 关键词: B细胞成熟抗原, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein, CD269, Tnfrsf17, Bcm, Bcma, Human TNFRSF17 Protein, His Tag, Flag Tag, Recombinant Protein, KMP2243 物种: Human 宿主: HEK293 Cells 规格: 50ug, 100ug, 200ug 纯化方式: Affinity purification 纯度: >95% as determined by SDS-PAGE 内毒素水平: <1.0 EU/ug determined by the LAL method 缓冲体系: PBS, pH7.4 Uniprot: Q02223 SDS-PAGE: KMP2243 SDS-PAGE image1.png 功能: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. 产品背景: B cell maturation antigen(BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid(aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation. 保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. 运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. 说明: This product is for research use only. 官网链接: http://www.kmdbioscience.cn/ 参考文献: 1.Nature 404:995-999 (2000) 2.J. Immunol. 165:1322-1330 (2000) 3.Nat. Immunol. 1:252-256 (2000)