产品编号: KMP2253 产品名称: Human Biotinylated FGL1 Protein, Avi Tag, His Tag 中文名称: 生物素化重组人FGL1蛋白 中文全称: 生物素化重组人纤维蛋白原样 1蛋白 关键词: 纤维蛋白原样 1, Fibrinogen-like protein 1, FGL1, HP-041, Hepassocin, HFREP-1, LFIRE-1, Human Biotinylated FGL1 Protein, Avi Tag, His Tag, Recombinant Protein, KMP2253 物种: Human 宿主: HEK293 Cells 规格: 50ug, 100ug, 200ug 纯化方式: Affinity purification 纯度: >90% as determined by SDS-PAGE 内毒素水平: <1.0 EU/ug determined by the LAL method 缓冲体系: 20mM Tris, 300mM NaCl, 10% Glycerol, 2mM EDTA, pH8.0 Uniprot: Q08830 SDS-PAGE: KMP2253 SDS-PAGE image1.png 功能: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). 产品背景: Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3. 保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. 运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. 说明: This product is for research use only. 官网链接: http://www.kmdbioscience.cn/ 参考文献: 1.Biochim. Biophys. Acta 1520:45-53 (2001) 2.Gut 59:817-826 (2010) 3.Cell 0:0-0 (2018)