产品编号: KMP2275 产品名称: Human Biotinylated ROR1 Protein, His Tag, Avi Tag 中文名称: 生物素化重组人ROR1蛋白 中文全称: 生物素化重组人受体酪氨酸激酶样孤儿受体蛋白 关键词: 受体酪氨酸激酶样孤儿受体, Inactive tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1, Human Biotinylated ROR1 Protein, His Tag, Avi Tag, Recombinant Protein, KMP2275 物种: Human 宿主: HEK293 Cells 规格: 50ug, 100ug, 200ug 纯化方式: Affinity purification 纯度: >95% as determined by SDS-PAGE 内毒素水平: <1.0 EU/ug determined by the LAL method 缓冲体系: PBS, pH7.4 Uniprot: Q01973 SDS-PAGE: KMP2275 SDS-PAGE image1.png 功能: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). 产品背景: Receptor tyrosine kinase-like orphan receptor 1(ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases(RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids(aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain(ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. 保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. 运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. 说明: This product is for research use only. 官网链接: http://www.kmdbioscience.cn/ 参考文献: 1.PLoS ONE 9:E102695-E102695 (2014) 2.Proc. Natl. Acad. Sci. U.S.A. 113:5993-5998 (2016)