| 基因名 | MICA |
| 别名 | HLA class I antigen;FLJ36918;FLJ60820;MGC111087;MGC21250;MHC class I chain related gene A protein;MHC class I chain related protein A;MHC class I chain related protein A HLA B HLA C;MHC class I polypeptide related sequence A;MHC class I polypeptide-related sequence A;MHC class I related protein;MIC A;MIC-A;micA;MICA_HUMAN;OTTHUMP00000029088;OTTHUMP00000044528;OTTHUMP00000165170;OTTHUMP00000165172;PERB11.1;Stress inducible class I homolog |
| 全名 | MHC class I polypeptide-related sequence A |
| 英文名称 | Recombinant Human MICA Protein |
| 中文名称 | MHC I类多肽相关序列A |
| 规格 | 10ug ; 50ug ; 100ug ; 1mg |
| 外观(性状) | Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
| 纯度 | ≥85% by SDS-PAGE. |
| 储存条件 | Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
| 运输条件 | 冷藏运输 |
| 浓度 | 1mg/ml by SDS-PAGE. |
| Swiss Prot | Q29983 |
| Gene ID | 4276 |
| 交叉反应 | Human |
| 分子量 | 34kDa |
| 区间范围 | 1-302aa |
| 背景说明 | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
| 研究领域 | 癌症研究与治疗 |
| 应用 | Immunology research |
| 来源 | E.coli |
| 纯化方法 | NI-NTA affinity purification |
| 溶剂 | Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 内毒素 | Not measured |
| 生物活性 | NO |
| 标签信息 | With a 6×His tag at the N/C-terminus. |
| 单位 | 支 |
| 属性分类 | 重组抗原 |
| Y-研究领域 | 癌症研究与治疗 |
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