| 基因名 | ESRRG |
| 别名 | ERR3，ERRG2，KIAA0832，NR3B3 |
| 全名 | estrogen-related receptor gamma |
| 英文名称 | Recombinant Human ESRRG Protein |
| 中文名称 | 雌激素相关受体γ |
| 规格 | 1mg ; 100ug ; 50ug ; 10ug |
| 外观(性状) | Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
| 纯度 | ≥85% by SDS-PAGE. |
| 储存条件 | Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
| 运输条件 | 冷藏运输 |
| 浓度 | 1mg/ml by SDS-PAGE. |
| Swiss Prot | P62508 |
| Gene ID | 2104 |
| 交叉反应 | Human Mouse Rat (Chimpanzee) |
| 分子量 | 39kDa |
| 区间范围 | 24-366aa |
| 背景说明 | This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. |
| 研究领域 | 癌症研究与治疗 |
| 应用 | Immunology research |
| 来源 | E.coli |
| 纯化方法 | NI-NTA affinity purification |
| 溶剂 | Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 内毒素 | Not measured |
| 生物活性 | NO |
| 标签信息 | With a 6×His tag at the N/C-terminus. |
| 单位 | 支 |
| 属性分类 | 重组抗原 |
| Y-研究领域 | 癌症研究与治疗 |
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