| 基因名 | SEMA4D |
| 别名 | C9orf164，CD100，SEMAJ |
| 全名 | sema domain，immunoglobulin domain (Ig)，transmembrane domain (TM) and short cytoplasmic domain，(semaphorin) 4D |
| 英文名称 | Recombinant Human SEMA4D Protein |
| 中文名称 | 跨膜蛋白SEMA4D |
| 规格 | 1mg ; 100ug ; 50ug ; 10ug |
| 外观(性状) | Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
| 纯度 | ≥85% by SDS-PAGE. |
| 储存条件 | Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
| 运输条件 | 冷藏运输 |
| 浓度 | 1mg/ml by SDS-PAGE. |
| Swiss Prot | Q92854 |
| Gene ID | 10507 |
| 交叉反应 | Human Mouse |
| 分子量 | 38kDa |
| 区间范围 | 360-710aa |
| 背景说明 | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). |
| 研究领域 | 炎症与自身免疫疾病 |
| 应用 | Immunology research |
| 来源 | E.coli |
| 纯化方法 | NI-NTA affinity purification |
| 溶剂 | Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 内毒素 | Not measured |
| 生物活性 | NO |
| 标签信息 | With a 6×His tag at the N/C-terminus. |
| 单位 | 支 |
| 属性分类 | 重组抗原 |
| Y-研究领域 | 炎症与自身免疫疾病 |
