| 别名 | GDNF Family Receptor Alpha-2;GDNF Receptor Alpha-2;GDNFR-Alpha-2;GFR-Alpha-2;GDNF Receptor Beta;GDNFR-Beta;Neurturin Receptor Alpha;NRTNR-Alpha;NTNR-Alpha;RET Ligand 2;TGF-Beta-Related Neurotrophic Factor Receptor 2;GFRA2;GDNFRB;RETL2;TRNR2 |
| 英文名称 | Recombinant Human GFRα-2/GDNF R α-2/GDNF family receptor alpha-2/GFRA2 |
| 中文名称 | Recombinant Human GFRα-2/GDNF R α-2/GDNF family receptor alpha-2/GFRA2 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | 冷藏运输 |
| 背景说明 | Members of the glial cell line-derived neurotrophic factor (GDNF) family，including GDNF and Neurturin，play key roles in the control of vertebrate neuronal survivial and differentiation.GDNF is a glycosylated，disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors.Three receptors for these factors，GFRα-1，GFRα-2，and GFRα-3 have been identified.The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage.Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret.GFR-3 is expressed only during development.GFRα-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
