| 别名 | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1;SHP Substrate 1;Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs;CD172 Antigen-Like Family Member A;Inhibitory Feceptor SHPS-1;Macrophage Fusion Receptor;Signal-Regulatory Protein Alpha-1;Sirp-Alpha-1;Signal-Regulatory Protein Alpha-2;Sirp-Alpha-2;Signal-Regulatory Protein Alpha-3;Sirp-Alpha-3;CD172a;SIRPA;MFR;SHPS1;SIRP |
| 英文名称 | Recombinant Mouse SIRP alpha/CD172a/SIRPA/Signal-Regulatory Protein α-1 |
| 中文名称 | 重组小鼠SIRP alpha/CD172a/SIRPA/Signal-Regulatory蛋白 α-1 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | 冷藏运输 |
| 背景说明 | Mouse Signal Regulatory Protein α (SIRPα) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain.Mouse SIRP alpha ECD shares 61%，75%，62%，61%，and 59% aa sequence identity with human，rat，equine，bovine，and porcine SIRP alpha，respectively.SIRPα can express in various tissues，mainly on brain and myeloid cells，including macrophages，neutrophils，dendritic and Langerhans cells.It also can detect in neurons，smooth muscle and endothelial cells.SIRPA is an immunoglobulin-like cell surface receptor for CD47.SIRPα acts as docking protein and induces translocation of PTPN6，PTPN11 and other binding partners from the cytosol to the plasma membrane.SIRPα shows adhesion of cerebellar neurons，neurite outgrowth and glial cell attachment.SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis，mast cell activation and dendritic cell activation |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
