| 别名 | Leptin receptor;LEP-R;HuB219;OB receptor;OB-R;CD295;LEPR;DB;OBR |
| 英文名称 | Recombinant Human Leptin Receptor/LEPR/CD295 |
| 中文名称 | Recombinant Human Leptin Receptor/LEPR/CD295 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | 冷藏运输 |
| 背景说明 | The Leptin receptor is a member of the Class I cytokine receptor family.It mediates the activities of Leptin，a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake，energy metabolism，angiogenesis，reproduction，hematopoiesis，bone metabolism，and immune function.The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide，an extracellular region with cytokine receptor homology (CRH)，multiple fibronectin type III domains and a WSXWS motif，a transmembrane domain，and a cytoplasmic domain that supports JAK/STAT signaling.Soluble Leptin R is the primary Leptin-binding protein in blood，where it maintains a pool of available bioactive Leptin，delays Leptin clearance from circulation，and down-regulates blood-brain transmission of Leptin.In humans，soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males.Soluble Leptin R is also found up-regulated in patients with chronic heart failure，end-stage renal disease，and anorexia.It is expressed by tumor-initiating stem cells，and is proposed as a link between cancer and obesity. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
