| 别名 | Transferrin receptor protein 1;TR;TfR;Trfr;T9;p90 |
| 英文名称 | Recombinant Human TFRC |
| 中文名称 | Recombinant Human TFRC |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,5% Trehalose,pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | 冷藏运输 |
| 背景说明 | Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa).TFRC regulated by cellular iron levels through binding of the iron regulatory proteins，IRP1 and IRP2，to iron-responsive elements in the 3'-UTR.It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen，DR1.It Interacts with SH3BP3 and STEAP3，facilitates TFRC endocytosis in erythroid precursor cells.Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes.Endosomal acidification leads to iron release.The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.Transferrin receptor is necessary for development of erythrocytes and the nervous system.A second ligand，the heditary hemochromatosis protein HFE，competes for binding with transferrin for an overlapping C-terminal binding site.It positively regulates T and B cell proliferation through iron uptake. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
